The generation of induced pluripotent stem cells (iPSCs) from somatic cells demonstrated
that adult mammalian cells can be reprogrammed to a pluripotent state by the enforced …

Pluripotent stem-cell lines can be obtained through the reprogramming of somatic cells from
different tissues and species by ectopic expression of defined factors. In theory, these cells …

Induced pluripotent stem cells offer unprecedented potential for disease research, drug
screening, toxicology and regenerative medicine. However, the process of reprogramming is …

Novel DNA sequencing techniques, referred to as “next-generation” sequencing (NGS),
provide high speed and throughput that can produce an enormous volume of sequences …

Direct reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) provides an
invaluable resource for regenerative medicine, enabling the generation of patient-specific …

Summary Ectopic expression of Oct4, Sox2, cMyc, and Klf4 confers a pluripotent state upon
several differentiated cell types, generating induced pluripotent stem cells (iPSCs)[1–8] …

Induction of pluripotency by transcription factors has become a commonplace method to
produce pluripotent stem cells. Great strides have been made in our understanding of the …

Genetic reprogramming of somatic cells to a pluripotent state (induced pluripotent stem cells
or iPSCs) by over-expression of specific genes has been accomplished using mouse and …

We report the derivation of induced pluripotent stem (iPS) cells from adult skin fibroblasts
using a single, polycistronic lentiviral vector encoding the reprogramming factors Oct4, Sox2 …

The unlimited proliferation capacity of embryonic stem cells (ESCs) combined with their
pluripotent differentiation potential in various lineages raised great interest in both the …