Single-cell RNA sequencing (scRNA-seq) has revolutionized our understanding of cellular
heterogeneity and the dynamics of gene expression, bearing profound significance in stem …

The evolution of a unique craniofacial complex in vertebrates made possible new ways of
breathing, eating, communicating and sensing the environment. The head and face develop …

Single cell chromatin accessibility profiling and transcriptome sequencing are the most
widely used technologies for single-cell genomics. Here, we present Microwell-seq3, a high …

We develop a large-scale single-cell ATAC-seq method by combining Tn5-based pre-
indexing with 10× Genomics barcoding, enabling the indexing of up to 200,000 nuclei …

High-throughput sequencing (HTS) technologies have been instrumental in investigating
biological questions at the bulk and single-cell levels. Comparative analysis of two HTS data …

Regenerative capacities and strategies vary dramatically across animals, as well as
between cell types, organs, and with age. In recent years, high-throughput single-cell …

This study examined nine prominent commercially available single-cell RNA sequencing
(scRNA-seq) kits across four technology groups. Each kit was characterized using …

Motivation Gene–enhancer interactions are central to transcriptional regulation. Current
multi-modal single-cell datasets that profile transcriptome and chromatin accessibility …

Genetic mutations are well known to influence tumorigenesis, tumor progression, treatment
response and relapse, but the role of epigenetic variation in cancer progression is still …

Single‐cell whole‐genome sequencing (scWGS) detects cell heterogeneity at the aspect of
genomic variations, which are inheritable and play an important role in life processes such …