Glioblastoma is a highly aggressive brain tumor that is characterized by its unparalleled
invasiveness. Invasive glioblastoma cells not only escape surgery and focal therapies but …

Hyaluronic acid (HA) is a natural polysaccharide and a key component of the extracellular
matrix (ECM) in many tissues. Therefore, HA-based biomaterials are extensively utilized to …

Glioblastoma (GBM) is the deadliest brain tumor for which there is no cure. Bioengineered
GBM models, such as hydrogel-encapsulated spheroids, that capture both cell-cell and cell …

Biomimetic materials have long been the (he) art of bioengineering. They usually aim at
mimicking in vivo conditions to allow in vitro culture, differentiation and expansion of cells …

In the last decade, hyaluronic acid (HA) has attracted an ever-growing interest in the
biomedical engineering field as a biocompatible, biodegradable, and chemically versatile …

Diffuse invasion of glioma cells into the brain parenchyma leads to nonresectable brain
tumors and poor prognosis of glioma disease. In vivo, glioma cells can adopt a range of …

The high mortality in glioblastoma multiforme (GBM) patients is primarily caused by
extensive infiltration into adjacent tissue and subsequent rapid recurrence. There are no …

Brain tumors' severity ranges from benign to highly aggressive and invasive. Bioengineering
tools can assist in understanding the pathophysiology of these tumors from outside the body …

Glioblastoma (GB) is an astrocytic brain tumour with a low survival rate, partly because of its
highly invasive nature. The GB tumour microenvironment (TME) includes its extracellular …

Treatments for lesions in central nervous system (CNS) are always faced with challenges
due to the anatomical and physiological particularity of the CNS despite the fact that several …