The comparison of DNA methylation patterns across cancer types (pan-cancer methylome
analyses) has revealed distinct subgroups of tumors that share similar methylation patterns …

Recent studies have shown that intratumor heterogeneity contributes to drug resistance in
advanced disease. Intratumor heterogeneity may foster the selection of a resistant subclone …

The evolutionary history of tumor cell populations can be reconstructed from patterns of
genetic alterations. In contrast to stable genetic events, epigenetic states are reversible and …

Exosomes, cell-derived vesicles of endosomal origin, are continuously released in the
extracellular environment and play a key role in intercellular crosstalk. In this study, we have …

REPRODUCTION Page 1 REPRODUCTION © 2016 Society for Reproduction and Fertility DOI:
10.1530/REP-15-0436 ISSN 1470–1626 (paper) 1741–7899 (online) Online version via …

In a developing human corpus luteum, a closely regulated cellular communication system
exists between the luteal steroidogenic cells and endothelial cells. This system guaranties …

Tumor tissues are constituted by a dynamic diversity of malignant and non-malignant cells,
which shape a puzzling biological ecosystem affecting cancer biology and response to …

Genetic variability, epigenetic variability, and gene expression variability (noise) are
generally considered independently in their relationship with phenotypic variation. However …

Hepatocellular carcinoma (HCC) is the most prevalent primary tumor of the liver, and is
steadily becoming one of the most lethal cancers worldwide. Liver resection, which is the …

Secreted protein acidic and rich in cysteine (SPARC) is a secreted matricellular glycoprotein
and plays a key role in the development of many tissues and organ types. However, the role …