From actin waves to mechanism and back: how theory aids biological understanding
Actin dynamics in cell motility, division, and phagocytosis is regulated by complex factors
with multiple feedback loops, often leading to emergent dynamic patterns in the form of …
with multiple feedback loops, often leading to emergent dynamic patterns in the form of …
[HTML][HTML] The excitable signal transduction networks: movers and shapers of eukaryotic cell migration
In response to a variety of external cues, eukaryotic cells display varied migratory modes to
perform their physiological functions during development and in the adult. Aberrations in cell …
perform their physiological functions during development and in the adult. Aberrations in cell …
Spatiotemporal dynamics of membrane surface charge regulates cell polarity and migration
During cell migration and polarization, numerous signal transduction and cytoskeletal
components self-organize to generate localized protrusions. Although biochemical and …
components self-organize to generate localized protrusions. Although biochemical and …
Ras suppression potentiates rear actomyosin contractility-driven cell polarization and migration
Ras has been extensively studied as a promoter of cell proliferation, whereas few studies
have explored its role in migration. To investigate the direct and immediate effects of Ras …
have explored its role in migration. To investigate the direct and immediate effects of Ras …
Quantitative structured illumination microscopy via a physical model-based background filtering algorithm reveals actin dynamics
Y Mo, K Wang, L Li, S Xing, S Ye, J Wen… - Nature …, 2023 - nature.com
Despite the prevalence of superresolution (SR) microscopy, quantitative live-cell SR
imaging that maintains the completeness of delicate structures and the linearity of …
imaging that maintains the completeness of delicate structures and the linearity of …
An excitable Ras/PI3K/ERK signaling network controls migration and oncogenic transformation in epithelial cells
Summary The Ras/PI3K/extracellular signal-regulated kinases (ERK) signaling network
plays fundamental roles in cell growth, survival, and migration and is frequently activated in …
plays fundamental roles in cell growth, survival, and migration and is frequently activated in …
A dynamic partitioning mechanism polarizes membrane protein distribution
T Banerjee, S Matsuoka, D Biswas, Y Miao… - Nature …, 2023 - nature.com
The plasma membrane is widely regarded as the hub of the numerous signal transduction
activities. Yet, the fundamental biophysical mechanisms that spatiotemporally …
activities. Yet, the fundamental biophysical mechanisms that spatiotemporally …
Periodicity, mixed-mode oscillations, and multiple timescales in a phosphoinositide-Rho GTPase network
C San Tong, XJ Xǔ, M Wu - Cell Reports, 2023 - cell.com
While rhythmic contractile behavior is commonly observed at the cellular cortex, the primary
focus has been on excitable or periodic events described by simple activator-delayed …
focus has been on excitable or periodic events described by simple activator-delayed …
Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration
A Bolado-Carrancio, OS Rukhlenko, E Nikonova… - Elife, 2020 - elifesciences.org
Migrating cells need to coordinate distinct leading and trailing edge dynamics but the
underlying mechanisms are unclear. Here, we combine experiments and mathematical …
underlying mechanisms are unclear. Here, we combine experiments and mathematical …
Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects
Z Jiao, H Cai, Y Long, OK Sirka… - Proceedings of the …, 2020 - National Acad Sciences
Cancer cells display novel characteristics which can be exploited for therapeutic advantage.
Isolated studies have shown that 1) the mevalonate pathway and 2) increased …
Isolated studies have shown that 1) the mevalonate pathway and 2) increased …