Establishing the different lineages of the early mammalian embryo takes place over several
days and several rounds of cell divisions from the fertilized egg. The resulting blastocyst …

The first few days of embryonic development in eutherian mammals are dedicated to the
specification and elaboration of the extraembryonic tissues. However, where the fetus ends …

Mammalian embryos change shape dramatically upon implantation. The cellular and
molecular mechanism underlying this transition are largely unknown. Here, we show that …

The first binary cell fate decision occurs at the morula stage and gives rise to two distinct
types of cells that constitute the trophectoderm (TE) and inner cell mass (ICM). The cell fate …

Abstract Background Trophoblast stem cells (TSCs), the precursors of trophoblast cells of
placenta, possess the potential to differentiate into various trophoblastic subtypes in vitro …

Two fundamental elements of pre-implantation embryogenesis are cells' intrinsic self-
organization program and their developmental plasticity, which allows embryos to …

The first stages of mammalian development, before implantation of the embryo in the
maternal uterus, result in the establishment of three cell populations in the blastocyst …

Cell fate decisions are the backbone of many developmental and disease processes. In
early mammalian development, precise gene expression changes underly the rapid division …

Purpose To investigate the transition of CDX2 expression patterns in mouse trophectoderm
(TE) and its regulatory mechanisms during implantation. Methods Mouse E3. 5–4.5 …

Bats are natural hosts for numerous zoonotic viruses, including henipaviruses, which are
highly pathogenic for humans, livestock, and other mammals but do not induce clinical …