Innate immunity is the first defense system against invading pathogens. Toll-like receptors
(TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition …

Immune checkpoint inhibitors have revolutionized the treatment of patients with advanced-
stage metastatic melanoma, as well as patients with many other solid cancers, yielding long …

Abstract CD4+ regulatory T cells (T regs) expressing the transcription factor FoxP3 are
highly immune suppressive and play central roles in the maintenance of self-tolerance and …

Highlights•The vital role of FOXP3+ CD25+ CD4+ regulatory T (Treg) cells in tumor immunity
is described.•FOXP3+ CD25+ CD4+ Treg cells are abundantly present in tumor tissues and …

Purpose: Aldesleukin, recombinant human IL2, is an effective immunotherapy for metastatic
melanoma and renal cancer, with durable responses in approximately 10% of patients; …

Pancreatic ductal adenocarcinoma (PDAC) is an incurable cancer resistant to traditional
treatments, although a limited number of early-stage patients can undergo radical resection …

Purpose: The goals of the study were to elucidate the immune mechanisms that contribute to
desirable complete remissions of murine colon tumors treated with single radiation dose of …

Regulatory T cells (Tregs) are key immunosuppressive cells that promote tumor growth by
hindering the effector immune response. Tregs utilize multiple suppressive mechanisms to …

The last fifteen years have seen a reemergence of interest in cancer immunosurveillance
and a broadening of this concept into one termed cancer immunoediting. The latter …

Glioma is one of the most common malignant tumors of the central nervous system and is
characterized by extensive infiltrative growth, neovascularization, and resistance to various …