In response to the energy demand triggered by developmental signals and environmental
stressors, the cells launch the mitochondrial biogenesis process. This is a self‐renewal …

Cancer is the second leading cause of death worldwide. Majority of recent research efforts in
the field aim to address why cancer resistance to therapy develops and how to overcome or …

It is now well established that tumours undergo changes in cellular metabolism 1. As this
can reveal tumour cell vulnerabilities and because many tumours exhibit enhanced glucose …

Accumulating evidence is indicating metformin to possess the potential ability in preventing
tumor development and suppressing cancer growth. However, the exact mechanism of its …

Parkinson's disease (PD) is the second most common neurodegenerative disorder. It is
characterized by the accumulation of intracellular α-synuclein aggregates and the …

The immune system and metabolism are highly integrated and multilevel interactions
between metabolic system and T lymphocyte signaling and fate exist. Accumulating …

Mitochondria are essential organelles involved in the maintenance of cell growth and
function, and have been investigated as therapeutic targets in various diseases. Recent …

Toll-like receptor (TLR) agonists induce metabolic reprogramming, which is required for
immune activation. We have investigated mechanisms that regulate metabolic adaptation …

Metformin is a hypoglycaemic agent used to treat type 2 diabetes mellitus (DM2) patients,
with a broad safety profile. Since previous epidemiological studies had shown that the …

Metabolic reprogramming is a unique but complex biochemical adaptation that allows solid
tumors to tolerate various stresses that challenge cancer cells for survival. Under conditions …