Polyunsaturated fatty acids (n-3 PUFAs) are long-chain polyunsaturated fatty acids with 18,
20 or 22 carbon atoms, which have been found able to counteract cardiovascular diseases …

The maintenance of physiological levels of nitric oxide (NO) produced by eNOS represents a
key element for vascular endothelial homeostasis. On the other hand, NO overproduction …

Nitric oxide (NO) is a pleiotropic janus-faced molecule synthesized by nitric oxide synthases
(NOS) which plays a critical role in a number of physiological and pathological processes in …

At the end of the 1980s, it was clearly demonstrated that cells produce nitric oxide and that
this gaseous molecule is involved in the regulation of the cardiovascular, immune and …

Insulin has important vascular actions to stimulate production of nitric oxide from
endothelium. This leads to capillary recruitment, vasodilation, increased blood flow, and …

Nitric oxide (NO) is a pleiotropic molecule critical to a number of physiological and
pathological processes. The last decade has witnessed major advances in dissecting NO …

Peroxynitrite (PN; ONOO−) and its reactive oxygen precursor superoxide (SO; O2•−) are
critically important in the development of pain of several etiologies including pain associated …

Tobacco smoking is a major cause of chronic obstructive pulmonary disease (COPD) and
atherosclerotic cardiovascular disease (ASCVD). These diseases share common …

Oxidative stress, neuroinflammation, and excitotoxicity are frequently considered distinct but
common hallmarks of several neurological disorders, including Parkinson's disease …

Oxidative stress plays a key role in the pathogenesis of aging and many metabolic diseases;
therefore, an effective antioxidant therapy would be of great importance in these …