The vascular endothelium has several important functions, including hemostasis. The
homeostasis of hemostasis is based on a fine balance between procoagulant and …

Thrombin is increased in the brain after hemorrhagic and ischemic stroke primarily due to
the prothrombin entry from blood either with a hemorrhage or following blood-brain barrier …

The neonatal hemostatic system is strikingly different from that of adults. Among other
differences, neonates exhibit hyporeactive platelets and decreased levels of coagulation …

Birth asphyxia causes hypoxic-ischemic encephalopathy and multiorgan failure. The most
studied organ affected by hypoxia is the cardiovascular system, and the resulting …

Severe congenital protein C deficiency (SCPCD) is rare and there is currently substantial
variation in the management of this condition. A joint project by three Scientific and …

The assessment of hemostatic disorders in neonates is crucial, but remains challenging for
clinicians. Although the concept of developmental hemostasis is widely accepted among …

Injury to a fetus or neonate during delivery can be due to several factors involving the fetus,
placenta, mother, and/or instrumentation. Birth asphyxia results in hypoxia and ischemia …

Premature birth is a worldwide health issue, posing a high mortality risk for newborns, as
well as causing emotional and financial difficulties, and long-term health issues for patients …

Intrauterine growth restriction (IUGR) affects nearly 10 to 15% of pregnancies and is
responsible for many short-and long-term adverse consequences, including hemostatic …

Background The hemostatic system is complex and evolves continuously since gestation
and well into the adult years, in a process known as “developmental hemostasis.” Data …