Paracetamol (acetaminophen): A familiar drug with an unexplained mechanism of action

SS Ayoub - Temperature, 2021 - Taylor & Francis
Paracetamol (acetaminophen) is undoubtedly one of the most widely used drugs worldwide.
As an over-the-counter medication, paracetamol is the standard and first-line treatment for …

Why paracetamol (acetaminophen) is a suitable first choice for treating mild to moderate acute pain in adults with liver, kidney or cardiovascular disease …

J Alchin, A Dhar, K Siddiqui… - Current medical research …, 2022 - Taylor & Francis
Acute pain is among the most common reasons that people consult primary care physicians,
who must weigh benefits versus risks of analgesics use for each patient. Paracetamol …

Non-contact infrared assessment of human body temperature: The journal Temperature toolbox

J Foster, AB Lloyd, G Havenith - Temperature, 2021 - Taylor & Francis
The assessment of human internal/core temperature (T core) is relevant in many scientific
disciplines, but also for public health authorities when attempting to identify individuals with …

Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition?

CJ Esh, BCR Chrismas, AR Mauger… - Pharmacology …, 2021 - Wiley Online Library
The precise mechanistic action of acetaminophen (ACT; paracetamol) remains debated.
ACT's analgesic and antipyretic actions are attributed to cyclooxygenase (COX) inhibition …

Acetaminophen (paracetamol): use beyond pain management and dose variability

CJ Esh, AR Mauger, RA Palfreeman… - Frontiers in …, 2017 - frontiersin.org
Inappropriate prescribing of analgesics or self-administration through over the counter
formulations results in regular often negative reporting within the media. Indeed, their abuse …

Paracetamol: Unconventional uses of a well-known drug

S Bloukh, M Wazaify, C Matheson - International Journal of …, 2021 - academic.oup.com
Objectives To describe and map what is known about unconventional uses of paracetamol
through a scoping review of published literature by adopting adopted a PRISMA systematic …

The influence of environmental and core temperature on cyclooxygenase and PGE2 in healthy humans

CJ Esh, BCR Chrismas, AR Mauger, A Cherif… - Scientific Reports, 2021 - nature.com
Whether cyclooxygenase (COX)/prostaglandin E2 (PGE2) thermoregulatory pathways,
observed in rodents, present in humans? Participants (n= 9) were exposed to three …

Paracetamol-Induced Hypothermia in Rodents: A Review on Pharmacodynamics

L Coman, H Păunescu, CIV Ghiță, RC Țincu, S Vasile… - Processes, 2022 - mdpi.com
Paracetamol can induce hypothermia in humans and rodents. The study's aim is to review
the mechanisms of paracetamol-induced hypothermia in rodents or the results issued from …

H89 dihydrochloride hydrate and calphostin C lower the body temperature through TRPV1

D Bao, W Zhao, C Dai, H Wan… - Molecular Medicine …, 2018 - spandidos-publications.com
The transient receptor potential vanilloid (TRPV1) serves as a negative regulator of body
temperature, and during fever conditions its expression can lead to a decrease in …

Gambaran Bahan Kimia Obat Parasetamol Dalam Jamu Pegal Linu Yang Dijual Di Pasar Gladak

NP Tjahjani, CWP Nasution - Jurnal Farmasetis, 2020 - journal.stikeskendal.ac.id
Salah satu jamu yang digemari oleh masyarakat adalah jamu pegal linu. Jamu yang
digemari masyarakat adalah jamu yang cepat memberikan efek pengobatan, sehingga ada …