Polycystic ovary syndrome (PCOS) is now recognized as an important metabolic as well as
reproductive disorder conferring substantially increased risk for type 2 diabetes. Affected …

Insulin resistance and the metabolic syndrome are complex metabolic traits and key risk
factors for the development of cardiovascular disease. They result from the interplay of …

Insulin resistance in muscle and liver and-cell failure represent the core pathophysiologic
defects in type 2 diabetes. It now is recognized that the-cell failure occurs much earlier and …

Type 2 diabetes mellitus has become an epidemic, and virtually no physician is without
patients who have the disease. Whereas insulin insensitivity is an early phenomenon partly …

A discussion of the pathogenesis of type 2 diabetes mellitus must start with a review of
mechanisms involved in the maintenance of normal glucose homeostasis in the basal or …

To identify previously unknown genetic loci associated with fasting glucose concentrations,
we examined the leading association signals in ten genome-wide association scans …

Type 2 diabetes mellitus is a major cause of morbidity and mortality worldwide, and the
prevalence is set to increase dramatically over the coming decades. Understanding the …

Individuals with serious mental illness experience excess morbidity and mortality, including
an increased prevalence of diabetes mellitus and cardiovascular disease. Cardiovascular …

OBJECTIVE—Type 2 diabetes in obese youth is an emerging problem. The metabolic and
anthropometric predictors of change in glucose tolerance status in obese youth are …

Diabetes mellitus is a major risk factor for coronary heart disease (CHD). The major form of
diabetes mellitus is type 2 diabetes mellitus (T2D), which is thus largely responsible for the …