Opportunities and challenges in long-read sequencing data analysis
Long-read technologies are overcoming early limitations in accuracy and throughput,
broadening their application domains in genomics. Dedicated analysis tools that take into …
broadening their application domains in genomics. Dedicated analysis tools that take into …
Chromatin accessibility profiling methods
L Minnoye, GK Marinov, T Krausgruber, L Pan… - Nature Reviews …, 2021 - nature.com
Chromatin accessibility, or the physical access to chromatinized DNA, is a widely studied
characteristic of the eukaryotic genome. As active regulatory DNA elements are generally …
characteristic of the eukaryotic genome. As active regulatory DNA elements are generally …
Utility of long-read sequencing for All of Us
Abstract The All of Us (AoU) initiative aims to sequence the genomes of over one million
Americans from diverse ethnic backgrounds to improve personalized medical care. In a …
Americans from diverse ethnic backgrounds to improve personalized medical care. In a …
A comprehensive evaluation of long read error correction methods
Background Third-generation single molecule sequencing technologies can sequence long
reads, which is advancing the frontiers of genomics research. However, their high error rates …
reads, which is advancing the frontiers of genomics research. However, their high error rates …
Metagenomics: a tool for exploring key microbiome with the potentials for improving sustainable agriculture
BC Nwachukwu, OO Babalola - Frontiers in Sustainable Food …, 2022 - frontiersin.org
Microorganisms are immense in nature and exist in every imaginable ecological niche,
performing a wide range of metabolic processes. Unfortunately, using traditional …
performing a wide range of metabolic processes. Unfortunately, using traditional …
DNA metabarcoding for the characterization of terrestrial microbiota—pitfalls and solutions
Soil-borne microbes are major ecological players in terrestrial environments since they cycle
organic matter, channel nutrients across trophic levels and influence plant growth and …
organic matter, channel nutrients across trophic levels and influence plant growth and …
A comparative evaluation of hybrid error correction methods for error-prone long reads
S Fu, A Wang, KF Au - Genome biology, 2019 - Springer
Background Third-generation sequencing technologies have advanced the progress of the
biological research by generating reads that are substantially longer than second …
biological research by generating reads that are substantially longer than second …
Direct diagnostic tests for Lyme disease
SE Schutzer, BA Body, J Boyle… - Clinical Infectious …, 2019 - academic.oup.com
Borrelia burgdorferi was discovered to be the cause of Lyme disease in 1983, leading to
seroassays. The 1994 serodiagnostic testing guidelines predated a full understanding of key …
seroassays. The 1994 serodiagnostic testing guidelines predated a full understanding of key …
Application of high-throughput sequencing technologies and analytical tools for pathogen detection in urban water systems: Progress and future perspectives
The ubiquitous presence of pathogenic microorganisms, such as viruses, bacteria, fungi,
and protozoa, in urban water systems poses a significant risk to public health. The …
and protozoa, in urban water systems poses a significant risk to public health. The …
A journey on the skin microbiome: pitfalls and opportunities
D Pistone, G Meroni, S Panelli, E D'Auria… - International journal of …, 2021 - mdpi.com
The human skin microbiota is essential for maintaining homeostasis and ensuring barrier
functions. Over the years, the characterization of its composition and taxonomic diversity has …
functions. Over the years, the characterization of its composition and taxonomic diversity has …