Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology

C Settembre, RM Perera - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …

Anatomy and physiology of the human eye: effects of mucopolysaccharidoses disease on structure and function–a review

CE Willoughby, D Ponzin, S Ferrari… - Clinical & …, 2010 - Wiley Online Library
The current paper provides an overview of current knowledge on the structure and function
of the eye. It describes in depth the different parts of the eye that are involved in the ocular …

[PDF][PDF] Федеральные клинические рекомендации по оказания медицинской помощи детям с Желчекаменной болезнью

АА Баранов, ЛС Намазова-Баранова - МЗ РФ, Союз педиатров …, 2015 - astgmu.ru
Данные клинические рекомендации подготовлены совместно с Всероссийской
ассоциацией для больных муковисцидозом, рассмотрены и утверждены на заседании …

Analysis of deep learning techniques for prediction of eye diseases: A systematic review

A Bali, V Mansotra - Archives of Computational Methods in Engineering, 2024 - Springer
The prediction and early diagnosis of eye diseases are critical for effective treatment and
prevention of vision loss. The identification of eye diseases has recently been the subject of …

Autophagy in the retinal pigment epithelium: A new vision and future challenges

D Intartaglia, G Giamundo, I Conte - The FEBS journal, 2022 - Wiley Online Library
The retinal pigment epithelium (RPE) is a highly specialized monolayer of polarized,
pigmented epithelial cells that resides between the vessels of the choriocapillaris and the …

Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: implications for glaucoma pathogenesis

K Porter, J Nallathambi, Y Lin, PB Liton - Autophagy, 2013 - Taylor & Francis
Increasing evidence suggests oxidative damage as a key factor contributing to the failure of
the conventional outflow pathway tissue to maintain appropriate levels of intraocular …

The physiological and pathophysiological roles of the autophagy lysosomal system in the conventional aqueous humor outflow pathway: More than cellular clean up

MS Shim, PB Liton - Progress in retinal and eye research, 2022 - Elsevier
During the last few years, the autophagy lysosomal system is emerging as a central cellular
pathway with roles in survival, acting as a housekeeper and stress response mechanism …

[HTML][HTML] Autophagic dysregulation in glaucomatous trabecular meshwork cells

K Porter, J Hirt, WD Stamer, PB Liton - Biochimica et Biophysica Acta (BBA) …, 2015 - Elsevier
Primary open angle glaucoma (POAG) is a degenerative disease commonly associated with
aging and elevated intraocular pressure (IOP). Higher resistance to aqueous humor (AH) …

Expanding sialidosis spectrum by genome-wide screening: NEU1 mutations in adult-onset myoclonus

L Canafoglia, A Robbiano, D Pareyson, F Panzica… - Neurology, 2014 - AAN Enterprises
Objective: To identify the genetic cause of a familial form of late-onset action myoclonus in 2
unrelated patients. Both probands had 2 siblings displaying a similar disorder. Extensive …

[HTML][HTML] Through the Smoke: An In-Depth Review on Cigarette Smoking and Its Impact on Ocular Health

A Kulkarni, S Banait - Cureus, 2023 - ncbi.nlm.nih.gov
Smoking is a widespread and pervasive habit, impacting health across various care settings,
including acute care, subacute care, home-based care, and long-term care. Smoking is a …