Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer

F Wu, J Yang, J Liu, Y Wang, J Mu, Q Zeng… - … and Targeted Therapy, 2021 - nature.com
To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME),
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …

Cancer-associated fibroblasts: overview, progress, challenges, and directions

Q Ping, R Yan, X Cheng, W Wang, Y Zhong… - Cancer gene …, 2021 - nature.com
Tumors are one of the main causes of death in humans. The development of safe and
effective methods for early diagnosis and treatment of tumors is a difficult problem that needs …

CAFs interacting with TAMs in tumor microenvironment to enhance tumorigenesis and immune evasion

G Gunaydin - Frontiers in oncology, 2021 - frontiersin.org
Cancer associated fibroblasts (CAFs) and tumor associated macrophages (TAMs) are
among the most important and abundant players of the tumor microenvironment. CAFs as …

Cancer-associated fibroblasts: the chief architect in the tumor microenvironment

M Sarkar, T Nguyen, E Gundre, O Ogunlusi… - Frontiers in Cell and …, 2023 - frontiersin.org
Stromal heterogeneity of tumor microenvironment (TME) plays a crucial role in malignancy
and therapeutic resistance. Cancer-associated fibroblasts (CAFs) are one of the major …

Poly (pentahydropyrimidine)‐Based Hybrid Hydrogel with Synergistic Antibacterial and Pro‐Angiogenic Ability for the Therapy of Diabetic Foot Ulcers

W Li, H Chen, J Cai, M Wang, X Zhou… - Advanced Functional …, 2023 - Wiley Online Library
Bacterial infection and impaired angiogenesis make the treatment of diabetic foot ulcers
(DFU) extremely challenging. Cationic polymers are expected to treat infected wounds due …

Extracellular matrix profiles determine risk and prognosis of the squamous cell carcinoma subtype of non-small cell lung carcinoma

AL Parker, E Bowman, A Zingone, BM Ryan… - Genome medicine, 2022 - Springer
Abstract Background Squamous cell carcinoma (SqCC) is a subtype of non-small cell lung
cancer for which patient prognosis remains poor. The extracellular matrix (ECM) is critical in …

Cancer-associated fibroblasts: master tumor microenvironment modifiers

K Wright, T Ly, M Kriet, A Czirok, SM Thomas - Cancers, 2023 - mdpi.com
Simple Summary Cancer cells rely on the surrounding environment to grow and spread.
This environment contains structural components, secreted factors, immune cells, and other …

Decoding the spatiotemporal heterogeneity of tumor-associated macrophages

X Chu, Y Tian, C Lv - Molecular Cancer, 2024 - Springer
Tumor-associated macrophages (TAMs) are pivotal in cancer progression, influencing tumor
growth, angiogenesis, and immune evasion. This review explores the spatial and temporal …

Cancer-associated fibroblast: role in prostate cancer progression to metastatic disease and therapeutic resistance

M Bedeschi, N Marino, E Cavassi, F Piccinini, A Tesei - Cells, 2023 - mdpi.com
Prostate cancer (PCa) is one of the most common cancers in European males. Although
therapeutic approaches have changed in recent years, and several new drugs have been …

[HTML][HTML] FGF/FGFR signaling: From lung development to respiratory diseases

L Yang, F Zhou, D Zheng, D Wang, X Li, C Zhao… - Cytokine & growth factor …, 2021 - Elsevier
The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling system
regulates a variety of biological processes, including embryogenesis, angiogenesis, wound …