[HTML][HTML] Teprotumumab: interpreting the clinical trials in the context of thyroid eye disease pathogenesis and current therapies
BJ Winn, RC Kersten - Ophthalmology, 2021 - Elsevier
Teprotumumab, a monoclonal antibody targeted against the insulin-like growth factor 1 (IGF-
1) receptor, was recently approved by the United States Food and Drug Administration for …
1) receptor, was recently approved by the United States Food and Drug Administration for …
Systematic review and meta-analysis of peripheral blood DNA methylation studies in inflammatory bowel disease
V Joustra, IL Hageman, J Satsangi… - Journal of Crohn's …, 2023 - academic.oup.com
Abstract Background and Aims Over the past decade, the DNA methylome has been
increasingly studied in peripheral blood of inflammatory bowel disease [IBD] patients …
increasingly studied in peripheral blood of inflammatory bowel disease [IBD] patients …
Effects of molecular weight of chitosan on anti-inflammatory activity and modulation of intestinal microflora in an ulcerative colitis model
W Niu, Y Dong, Z Fu, J Lv, L Wang, Z Zhang… - International Journal of …, 2021 - Elsevier
This study investigated the therapeutic effects and mechanisms of chitosans (CSs) with
different molecular weights on ulcerative colitis (UC). Three size classes of CSs (Mw≤ 3, 50 …
different molecular weights on ulcerative colitis (UC). Three size classes of CSs (Mw≤ 3, 50 …
Association between proton pump inhibitor use during early pregnancy and risk of congenital malformations
Importance Proton pump inhibitors (PPIs) are increasingly used during pregnancy; however,
several observational studies have raised concerns about an increased risk of specific types …
several observational studies have raised concerns about an increased risk of specific types …
Age determines the risk of familial inflammatory bowel disease—a nationwide study
J Halfvarson, JF Ludvigsson, F Bresso… - Alimentary …, 2022 - Wiley Online Library
Summary Background and Aims To estimate familial aggregation of inflammatory bowel
disease (IBD), we performed a nationwide, case–control study and examined the odds for …
disease (IBD), we performed a nationwide, case–control study and examined the odds for …
New-onset of inflammatory bowel disease in a patient treated with teprotumumab for thyroid associated ophthalmopathy
DC Ashraf, I Jankovic, N El-Nachef… - Ophthalmic Plastic & …, 2021 - journals.lww.com
DISCUSSION OAML is a low-grade NHL consisting of small B-cell lymphocytes. Although
only 8% of MALT lymphomas involve the ocular adnexa, OAML constitutes 60%–70% of …
only 8% of MALT lymphomas involve the ocular adnexa, OAML constitutes 60%–70% of …
Differences of clinical phenotype between familial and sporadic Crohn's disease in East China
S Dong, X Xiang, Y Zhang, R Liu, L Ye… - International Journal of …, 2024 - Springer
Purpose Family history is one of the strongest risk factors for inflammatory bowel diseases
(IBD) while studies about the clinical phenotype of familial IBD are limited. This study aimed …
(IBD) while studies about the clinical phenotype of familial IBD are limited. This study aimed …
Healthy First-Degree Relatives From Multiplex Families vs Simplex Families Have a Higher Subclinical Intestinal Inflammation, a Distinct Fecal Microbial Signature …
PA Olivera, H Martinez-Lozano, H Leibovitzh, M Xue… - Gastroenterology, 2024 - Elsevier
Background & Aims Unaffected first-degree relatives (FDRs) from families with≥ 2 affected
FDRs with Crohn's disease (CD, multiplex families) have a high risk of developing CD …
FDRs with Crohn's disease (CD, multiplex families) have a high risk of developing CD …
Familial Risk of Gout and Interaction With Obesity and Alcohol Consumption: A Population‐Based Cohort Study in Korea
KH Kim, IA Choi, HJ Kim, H Swan… - Arthritis Care & …, 2023 - Wiley Online Library
Objective Population‐based studies of the familial aggregation of gout are scarce, and
gene/environment interactions are not well studied. This study was undertaken to evaluate …
gene/environment interactions are not well studied. This study was undertaken to evaluate …
Shift to a younger age and regional differences in inflammatory bowel disease in Korea: using healthcare administrative data
SH Kim, Y Park, SP Kim, SH Lee, SH Oh… - Digestive Diseases and …, 2022 - Springer
Background Research using healthcare administrative data with a validated algorithm can
reveal the real-world data of rare diseases. Aims We investigated an accurate algorithm for …
reveal the real-world data of rare diseases. Aims We investigated an accurate algorithm for …