Advances in protozoan epigenetic targets and their inhibitors for the development of new potential drugs

C Gaona-López, LK Vazquez-Jimenez… - Pharmaceuticals, 2023 - mdpi.com
Protozoan parasite diseases cause significant mortality and morbidity worldwide. Factors
such as climate change, extreme poverty, migration, and a lack of life opportunities lead to …

Monoketone Curcuminoids: An Updated Review of Their Synthesis and Biological Activities

TM Vieira, LS Tanajura, VCG Heleno… - Future …, 2024 - mdpi.com
Curcumin (or diferuloylmethane), a component of Curcuma longa L. rhizomes, displays
various biological and pharmacological activities. However, it is poorly bioavailable and …

Dibenzylideneacetone Overcomes Botrytis cinerea Infection in Cherry Tomatoes by Inhibiting Chitinase Activity

X Niu, Z Wang, C Wang, H Wang - Journal of Agricultural and …, 2023 - ACS Publications
Chitinase, a crucial component of the fungal cell wall and septa, plays an important role in
fungal germination by hydrolyzing chitin to provide carbon and energy for fungal growth and …

Chemoselective Synthesis and Anti-Kinetoplastidal Properties of 2,6-Diaryl-4H-tetrahydro-thiopyran-4-one S-Oxides: Their Interplay in a Cascade of Redox …

T Gendron, DA Lanfranchi, NI Wenzel, H Kessedjian… - Molecules, 2024 - mdpi.com
2, 6-Diaryl-4 H-tetrahydro-thiopyran-4-ones and corresponding sulfoxide and sulfone
derivatives were designed to lower the major toxicity of their parent anti-kinetoplatidal …

Tractable Quinolone Hydrazides Exhibiting Sub‐Micromolar and Broad Spectrum Antitrypanosomal Activities

KA Chirwa, KR Francisco, PS Dube, H Park… - …, 2024 - Wiley Online Library
Abstract Nagana and Human African Trypanosomiasis (HAT), caused by (sub) species of
Trypanosoma, are diseases that impede human and animal health, and economic growth in …

Insight into the Corrosion Inhibition of Dibenzylidene Acetone for Carbon Steel in a Sulfuric Acid Environment: Synthesis, Experimental, and Theoretical Studies

Z Ait El Caid, D Benmessaoud Left, A Thoume… - Journal of Bio-and Tribo …, 2024 - Springer
In this study, a thorough evaluation was conducted for the corrosion inhibition potential of
(1E, 4E)-1, 5-diphenylpenta-1, 4-dien-3-one compound, commonly referred to as …

Design, Synthesis, and Evaluation of An Anti‐trypanosomal [1, 2, 4] Triazolo [1, 5‐a] pyrimidine Probe for Photoaffinity Labeling Studies.

B Lucero, KR Francisco, C Varricchio, LJ Liu… - …, 2024 - Wiley Online Library
Studies have shown that depending on the substitution pattern, microtubule (MT)‐targeting
1, 2, 4‐triazolo [1, 5‐a] pyrimidines (TPDs) can produce different cellular responses in …