Müller glial cells span the entire thickness of the tissue, and ensheath all retinal neurons, in
vertebrate retinae of all species. This morphological relationship is reflected by a multitude …

Müller cells are active players in normal retinal function and in virtually all forms of retinal
injury and disease. Reactive Müller cells protect the tissue from further damage and …

Neurotrophic factors play key roles in the development and survival of neurons. The potent
neuroprotective effects of neurotrophic factors, including brain-derived neurotrophic factor …

Neurotrophic factors are agents with a promising ability to retard progression of
neurodegenerative diseases and are effective in slowing photoreceptor degeneration in …

Importance Macular telangiectasia type 2 (MacTel 2) is a rare disease in which
abnormalities of the retinal vasculature play a key role. The vascular abnormalities are …

Activation of microglia commonly occurs in response to a wide variety of pathological stimuli
including trauma, axotomy, ischemia, and degeneration in the CNS. In the retina, prolonged …

[Frontiers in Bioscience 6, e77-92, October 1, 2001] 77 ROLE OF MÜLLER CELLS IN RETINAL
DEGENERATIONS Andreas Bringmann and And Page 1 [Frontiers in Bioscience 6, e77-92 …

Injury-induced downregulation of neurotrophin receptors may limit the response of neurons
to trophic factors, compromising their ability to survive. We tested this hypothesis in a model …

The central retina in primates is adapted for high acuity vision. The most significant
adaptations to neural retina in this respect are: 1. The very high density of cone …

Pigment epithelium-derived factor (PEDF) is a 50-kDa protein encoded by a single gene that
shows strong conservation across phyla from fish to mammals. It is secreted by the retinal …