Visualizing the structure and dynamics of biomolecules is critical to understand biological
function, and requires methods to fluorescently label targets of interest in their cellular …

Cancer is a disease that seriously threatens human health. Over the past few decades,
researchers have continued to find ways to cure cancer. Currently, the most commonly used …

Proper three-dimensional structures are essential for maintaining the functionality of proteins
and for avoiding pathological consequences of improper folding. Misfolding and …

Covalent-type probes or sensors have been seldom reported for aggregated proteins.
Herein, we reported a series of covalent solvatochromic probes to selectively modify and …

Dual-state luminogens (DSEgens) are organic luminescent molecules that exhibit strong
emissions in both molecularly dispersed and aggregated states. The introduction of fluorine …

Protein aggregation in the cell is often manifested by the formation of subcellular punctate
structures. Herein, we modulated the solvatochromism and solubility of Nile Red fluorophore …

Protein misfolding and aggregation involve complex cellular processes with clinical
implications in various diseases. However, the detection of aggregated proteomes without …

The aggregation of amyloid proteins is highly related to the occurrence and development of
neurodegenerative and metabolic diseases. The detection of amyloid fibrils or monitoring …

Covalent sensors to detect and capture aggregated proteome in stressed cells are rare.
Herein, we construct a series of covalent fluorogenic sensors for aggregated proteins by …

The design and development of optical probes for sensing neurotoxic amyloid fibrils are
active and important areas of research and are undergoing continuous advancements. In …