Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …

Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a
fundamental role in mediating the onset and progression of disease. Microglia, which …

Parkinson's Disease (PD) is the second most common neurodegenerative disorder seen,
especially in the elderly. Tremor, shaking, movement problems, and difficulty with balance …

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder
worldwide. Clinically, it is characterized by a progressive degeneration of dopaminergic …

Osteopontin (OPN) also known by its official gene designation secreted phosphoprotein‐1
(SPP1) is a fascinating, multifunctional protein expressed in a number of cell types that …

As the professional phagocytes of the brain, microglia orchestrate the immunological
response and play an increasingly important role in maintaining homeostatic brain functions …

Microglial activation during neuroinflammation is crucial for coordinating the immune
response against neuronal tissue, and the initial response of microglia determines the …

Abstract LRRK2-G2019S is one of the most common Parkinson's disease (PD)-associated
mutations and has been shown to alter microglial functionality. However, the impact of …

Abstract Purpose of Review Neuroinflammation plays a significant role in Parkinson's
disease (PD) etiology along with mitochondrial dysfunction and impaired proteostasis. In this …

Microglia are resident immune cells in the brain and play a central role in the development
and surveillance of the nervous system. Extensive gliosis is a common pathological feature …