Synthetic cannabinoids: epidemiology, pharmacodynamics, and clinical implications

MS Castaneto, DA Gorelick, NA Desrosiers… - Drug and alcohol …, 2014 - Elsevier
Background Synthetic cannabinoids (SC) are a heterogeneous group of compounds
developed to probe the endogenous cannabinoid system or as potential therapeutics …

[HTML][HTML] Sex-dependent effects of cannabis and cannabinoids: a translational perspective

ZD Cooper, RM Craft - Neuropsychopharmacology, 2018 - nature.com
Recent policy changes have led to significant increases in the use of cannabis for both
medical and recreational purposes. Although men are more likely to endorse past month …

Sex differences and the endocannabinoid system in pain

HL Blanton, RC Barnes, MC McHann, JA Bilbrey… - Pharmacology …, 2021 - Elsevier
Cannabis use has been increasing in recent years, particularly among women, and one of
the most common uses of cannabis for medical purposes is pain relief. Pain conditions and …

Sex differences in cannabinoid pharmacology: a reflection of differences in the endocannabinoid system?

RM Craft, JA Marusich, JL Wiley - Life sciences, 2013 - Elsevier
Marijuana is the most widely used illicit drug in the US, and marijuana use by women is on
the rise. Women have been found to be more susceptible to the development of cannabinoid …

Sex differences in the acute effects of smoked cannabis: evidence from a human laboratory study of young adults

J Matheson, B Sproule, P Di Ciano, A Fares… - …, 2020 - Springer
Rationale Animal studies have found robust sex differences in the pharmacokinetics and
pharmacodynamics of Δ 9-tetrahydrocannabinol (THC). However, the human evidence …

Sex‐dependent effects of endocannabinoid modulation of conditioned fear extinction in rats

M Morena, AS Nastase, A Santori… - British Journal of …, 2021 - Wiley Online Library
Background and Purpose Women are twice as likely as men to develop post‐traumatic
stress disorder (PTSD) making the search for biological mechanisms underlying these …

Cannabis use, abuse, and withdrawal: Cannabinergic mechanisms, clinical, and preclinical findings

AJ Kesner, DM Lovinger - Journal of neurochemistry, 2021 - Wiley Online Library
Cannabis sativa is the most widely used illicit drug in the world. Its main psychoactive
component is delta‐9‐tetrahydrocannabinol (THC), one of over 100 phytocannabinoid …

[HTML][HTML] Combined non-psychoactive Cannabis components cannabidiol and β-caryophyllene reduce chronic pain via CB1 interaction in a rat spinal cord injury model

A Eeswara, A Pacheco-Spiewak, S Jergova, J Sagen - PloS one, 2023 - journals.plos.org
The most frequently reported use of medical marijuana is for pain relief. However, its
psychoactive component Δ9-tetrahydrocannabinol (THC) causes significant side effects …

Antinociceptive and immune effects of delta-9-tetrahydrocannabinol or cannabidiol in male versus female rats with persistent inflammatory pain

SC Britch, AG Goodman, JL Wiley, AM Pondelick… - … of Pharmacology and …, 2020 - ASPET
Chronic pain is the most common reason reported for using medical cannabis. The goal of
this research was to determine whether the two primary phytocannabinoids, delta-9 …

Sex-dependent effects of cannabis-induced analgesia

ZD Cooper, M Haney - Drug and alcohol dependence, 2016 - Elsevier
Background Preclinical studies demonstrate that cannabinoid-mediated antinociceptive
effects vary according to sex; it is unknown if these findings extend to humans. Methods This …