Chronic pain is one of the most prevalent health problems. The establishment of chronic
pain is complex. Current medication for chronic pain mainly dependent on anticonvulsants …

Nicotinic acetylcholine receptors (nAChRs) present as many different subtypes in the
nervous and immune systems, muscles and on the cells of other organs. In the immune …

Pain due to inflammation can be reduced by targeting the noncanonical nicotinic receptors
(NCNR) in cells of the immune system that regulate the synthesis and release of pro-and …

Nicotinic acetylcholine receptors containing α9 subunits are essential for the auditory
function and have been implicated, along with α7-containing nicotinic receptors, as potential …

Despite rapid advances in the field of chronic pain, it remains extremely challenging in the
clinic. Pain treatment strategies have not improved for decades as opioids remain the main …

Covering: up to November 2021 Since its isolation in 1818, strychnine has attracted the
attention of a plethora of chemists and pharmacologists who have established its structure …

There is an urgent need for nonopioid treatments for chronic and neuropathic pain to
provide effective alternatives amid the escalating opioid crisis. This study introduces novel …

Polymorphonuclear neutrophilic granulocytes (PMNs) are extremely important in defense of
the organism against infections and in inflammatory processes including neuroinflammation …

Background Donepezil, a cholinesterase inhibitor approved in Alzheimer's disease, has
demonstrated analgesic and preventive effects in animal models of oxaliplatin-induced …

A series of racemic benzofurans bearing N-methyl-2-pyrrolidinyl residue at C (2) or C (3) has
been synthesized and tested for affinity at the α4β2 and α3β4 nicotine acetylcholine …