Nuclear targeting of therapeutics provides a strategy for enhancing efficacy of molecules
active in the nucleus and minimizing off-target effects.'Active'nuclear-directed transport and …

Breast cancer (BC) is the most common malignancy among women worldwide. Like many
other cancers, BC therapy is challenging and sometimes frustrating. In spite of the various …

Trastuzumab is commonly used in the treatment of human epidermal growth factor receptor-
2 positive (HER-2+) breast cancer, but its efficacy is often limited by the emergence of …

Abstract MicroRNA-567 (miR-567) plays a decisive role in cancers whereas its role in non-
small cell lung cancer (NSCLC) is still unexplored. This study was therefore planned to …

Malfunction of nuclear–cytoplasmic transport contributes to many diseases including cancer.
Defective nuclear transport leads to changes in both the physiological levels and temporal …

Background Gastric cancer (GC) ranks the fifth most common cancer, and chemotherapy is
one of the most common treatments for GC. However, chemoresistance limits the …

Background A growing body of evidence has demonstrated the vital roles of circular RNAs
(circRNAs) in cancer progression and drug resistance. We intended to explore the roles and …

MicroRNAs play important roles in many biological processes. Their aberrant expression
can have oncogenic or tumor suppressor function directly participating to carcinogenesis …

Gastrointestinal (GI) cancers, including colorectal, gastric, hepatic, esophageal, and
pancreatic tumors, are responsible for large numbers of deaths around the world …

In recent years, plenty of studies found that circular RNAs (circRNAs) were essential players
in the initiation and progression of various cancers including the renal cell carcinoma (RCC) …