Towards early detection of neurodegenerative diseases: A gut feeling
S Makdissi, BD Parsons, F Di Cara - Frontiers in cell and …, 2023 - frontiersin.org
The gastrointestinal tract communicates with the nervous system through a bidirectional
network of signaling pathways called the gut-brain axis, which consists of multiple …
network of signaling pathways called the gut-brain axis, which consists of multiple …
Emerging genetic complexity and rare genetic variants in neurodegenerative brain diseases
Abstract Knowledge of the molecular etiology of neurodegenerative brain diseases (NBD)
has substantially increased over the past three decades. Early genetic studies of NBD …
has substantially increased over the past three decades. Early genetic studies of NBD …
GCH1 variants contribute to the risk and earlier age-at-onset of Parkinson's disease: a two-cohort case-control study
H Pan, Y Zhao, J Mei, Z Fang, Y Wang, X Zhou… - Translational …, 2020 - Springer
Background Common and rare variants of guanosine triphosphate cyclohydrolase 1 (GCH1)
gene may play important roles in Parkinson's disease (PD). However, there is a lack of …
gene may play important roles in Parkinson's disease (PD). However, there is a lack of …
Genetic modifiers and non-Mendelian aspects of CMT
Abstract Charcot-Marie-Tooth (CMT) neuropathies are amongst the most common inherited
diseases in neurology. While great strides have been made to identify the genesis of these …
diseases in neurology. While great strides have been made to identify the genesis of these …
Comprehensive genetic analysis of a Hungarian amyotrophic lateral sclerosis cohort
K Tripolszki, P Gampawar, H Schmidt, ZF Nagy… - Frontiers in …, 2019 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
characterized by the degeneration of motor neurons. Genetic factors play a key role in ALS …
characterized by the degeneration of motor neurons. Genetic factors play a key role in ALS …
Gelatin-derived carbon quantum dots mitigate herbicide-induced neurotoxic effects in vitro and in vivo
J Ahlawat, G Henriquez, A Varela-Ramirez… - Biomaterials …, 2022 - Elsevier
The herbicide and viologen, N, N′-dimethyl-4, 4′-bipyridinium dichloride (Paraquat) is
known to be toxic to neuronal cells by a multifactorial process involving an elevation in the …
known to be toxic to neuronal cells by a multifactorial process involving an elevation in the …
Targeting the microbiota-mitochondria crosstalk in neurodegeneration with senotherapeutics
J Homolak - Advances in Protein Chemistry and Structural Biology, 2023 - Elsevier
Neurodegenerative diseases are a group of age-related disorders characterized by a
chronic and progressive loss of function and/or structure of synapses, neurons, and glial …
chronic and progressive loss of function and/or structure of synapses, neurons, and glial …
A perspective on persistent toxicants in veterans and amyotrophic lateral sclerosis: identifying exposures determining higher ALS risk
Multiple studies indicate that United States veterans have an increased risk of developing
amyotrophic lateral sclerosis (ALS) compared to civilians. However, the responsible …
amyotrophic lateral sclerosis (ALS) compared to civilians. However, the responsible …
[HTML][HTML] The whole exome sequencing clarifies the genotype-phenotype correlations in patients with early-onset dementia
Our study aimed to identify the underlying causes in patients with early onset dementia by
clinical and genetic exploration. We recruited a group of 38 patients with early-onset …
clinical and genetic exploration. We recruited a group of 38 patients with early-onset …
Perspectives on the genomics of HSP beyond Mendelian inheritance
DM Bis-Brewer, S Züchner - Frontiers in neurology, 2018 - frontiersin.org
Hereditary Spastic Paraplegia is an extraordinarily heterogeneous disease caused by over
50 Mendelian genes. Recent applications of next-generation sequencing, large scale data …
50 Mendelian genes. Recent applications of next-generation sequencing, large scale data …