Vascular calcification: pathobiology of a multifaceted disease
LL Demer, Y Tintut - Circulation, 2008 - Am Heart Assoc
with the matrix and with the periodicity of negative charges on collagen. Crystals initially
form octacalcium phosphate [Ca8H2 (PO4) 6· 5H2O], which reorganizes and seeds epitaxial …
form octacalcium phosphate [Ca8H2 (PO4) 6· 5H2O], which reorganizes and seeds epitaxial …
Molecular imaging insights into early inflammatory stages of arterial and aortic valve calcification
SEP New, E Aikawa - Circulation research, 2011 - Am Heart Assoc
Traditional imaging modalities such as computed tomography, although perfectly adept at
identifying and quantifying advanced calcification, cannot detect the early stages of this …
identifying and quantifying advanced calcification, cannot detect the early stages of this …
Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo
Background—Arterial calcification is associated with cardiovascular events; however,
mechanisms of calcification in atherosclerosis remain obscure. Methods and Results—We …
mechanisms of calcification in atherosclerosis remain obscure. Methods and Results—We …
Calcific aortic valve stenosis: methods, models, and mechanisms
Calcific aortic valve stenosis (CAVS) is a major health problem facing aging societies. The
identification of osteoblast-like and osteoclast-like cells in human tissue has led to a major …
identification of osteoblast-like and osteoclast-like cells in human tissue has led to a major …
Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease
E Aikawa, M Nahrendorf, D Sosnovik, VM Lok… - Circulation, 2007 - Am Heart Assoc
Background—Visualizing early changes in valvular cell functions in vivo may predict the
future risk and identify therapeutic targets for prevention of aortic valve stenosis. Methods …
future risk and identify therapeutic targets for prevention of aortic valve stenosis. Methods …
Aortic valve disease and treatment: the need for naturally engineered solutions
JT Butcher, GJ Mahler, LA Hockaday - Advanced drug delivery reviews, 2011 - Elsevier
The aortic valve regulates unidirectional flow of oxygenated blood to the myocardium and
arterial system. The natural anatomical geometry and microstructural complexity ensures …
arterial system. The natural anatomical geometry and microstructural complexity ensures …
Pathogenesis of calcific aortic valve disease: a disease process comes of age (and a good deal more)
KD O'Brien - Arteriosclerosis, thrombosis, and vascular biology, 2006 - Am Heart Assoc
Background—Over the past 10 to 15 years, calcific aortic valve disease, which includes
aortic sclerosis and aortic stenosis, has come to be recognized as an active process, based …
aortic sclerosis and aortic stenosis, has come to be recognized as an active process, based …
[HTML][HTML] Calcific aortic valve disease: molecular mechanisms and therapeutic approaches
DA Lerman, S Prasad, N Alotti - European Cardiology Review, 2015 - ncbi.nlm.nih.gov
Calcification occurs in atherosclerotic vascular lesions and in the aortic valve. Calcific aortic
valve disease (CAVD) is a slow, progressive disorder that ranges from mild valve thickening …
valve disease (CAVD) is a slow, progressive disorder that ranges from mild valve thickening …
Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents
D Hakuno, N Kimura, M Yoshioka… - The Journal of …, 2010 - Am Soc Clin Investig
Valvular heart disease (VHD) is the term given to any disease process involving one or more
of the heart valves. The condition can be congenital or acquired, for example as a result of …
of the heart valves. The condition can be congenital or acquired, for example as a result of …
Calcific aortic valve stenosis in old hypercholesterolemic mice
Background—Hypercholesterolemia and old age are clinical risk factors for development of
aortic valve stenosis, and hypercholesterolemia is a putative therapeutic target. We tested …
aortic valve stenosis, and hypercholesterolemia is a putative therapeutic target. We tested …