Natural killer cell therapy for hematologic malignancies: successes, challenges, and the future
MG Lamb, HG Rangarajan, BP Tullius… - Stem Cell Research & …, 2021 - Springer
The adoptive transfer of natural killer (NK) cells is an emerging therapy in the field of
immuno-oncology. In the last 3 decades, NK cells have been utilized to harness the anti …
immuno-oncology. In the last 3 decades, NK cells have been utilized to harness the anti …
Fit-for-all iPSC-derived cell therapies and their evaluation in humanized mice with NK cell immunity
C Flahou, T Morishima, H Takizawa… - Frontiers in …, 2021 - frontiersin.org
Human induced pluripotent stem cells (iPSCs) can be limitlessly expanded and
differentiated into almost all cell types. Moreover, they are amenable to gene manipulation …
differentiated into almost all cell types. Moreover, they are amenable to gene manipulation …
Latency reversal plus natural killer cells diminish HIV reservoir in vivo
JT Kim, TH Zhang, C Carmona, B Lee, CS Seet… - Nature …, 2022 - nature.com
HIV is difficult to eradicate due to the persistence of a long-lived reservoir of latently infected
cells. Previous studies have shown that natural killer cells are important to inhibiting HIV …
cells. Previous studies have shown that natural killer cells are important to inhibiting HIV …
Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer's disease
Abstract Background Regulatory T cells (Tregs) play a neuroprotective role by suppressing
microglia and macrophage-mediated inflammation and modulating adaptive immune …
microglia and macrophage-mediated inflammation and modulating adaptive immune …
Innovative strategies to improve the clinical application of NK cell-based immunotherapy
Natural killer cells constitute a part of the innate immune system that mediates an effective
immune response towards virus-infected and malignant cells. In recent years, research has …
immune response towards virus-infected and malignant cells. In recent years, research has …
The application of autologous cancer immunotherapies in the age of memory-NK cells
GD Lizana-Vasquez, M Torres-Lugo, RB Dixon… - Frontiers in …, 2023 - frontiersin.org
Cellular immunotherapy has revolutionized the oncology field, yielding improved results
against hematological and solid malignancies. NK cells have become an attractive …
against hematological and solid malignancies. NK cells have become an attractive …
[HTML][HTML] Natural killer cell therapy: A new frontier for obesity-associated cancer
Natural killer (NK) cell infiltration of solid tumours is associated with better outcomes, placing
augmentation of NK cell abundance in tumours as an attractive immunotherapeutic …
augmentation of NK cell abundance in tumours as an attractive immunotherapeutic …
Metabolic adaptations determine whether natural killer cells fail or thrive within the tumor microenvironment
A Moinuddin, SM Poznanski, AL Portillo… - Immunological …, 2024 - Wiley Online Library
Natural Killer (NK) cells are a top contender in the development of adoptive cell therapies for
cancer due to their diverse antitumor functions and ability to restrict their activation against …
cancer due to their diverse antitumor functions and ability to restrict their activation against …
Proteome analysis of human natural killer cell derived extracellular vesicles for identification of anticancer effectors
JW Choi, S Lim, JH Kang, SH Hwang, KC Hwang… - Molecules, 2020 - mdpi.com
Cancer immunotherapy is a clinically validated therapeutic modality for cancer and has
been rapidly advancing in recent years. Adoptive transfer of immune cells such as T cells …
been rapidly advancing in recent years. Adoptive transfer of immune cells such as T cells …
Design and implementation of NK cell-based immunotherapy to overcome the solid tumor microenvironment
Simple Summary Cell therapy over the last few years has revolutionized the treatment of
blood cancers. However, efficacy against cancers of solid organs remains limited. These …
blood cancers. However, efficacy against cancers of solid organs remains limited. These …