Natural killer cell therapy for hematologic malignancies: successes, challenges, and the future

MG Lamb, HG Rangarajan, BP Tullius… - Stem Cell Research & …, 2021 - Springer
The adoptive transfer of natural killer (NK) cells is an emerging therapy in the field of
immuno-oncology. In the last 3 decades, NK cells have been utilized to harness the anti …

Fit-for-all iPSC-derived cell therapies and their evaluation in humanized mice with NK cell immunity

C Flahou, T Morishima, H Takizawa… - Frontiers in …, 2021 - frontiersin.org
Human induced pluripotent stem cells (iPSCs) can be limitlessly expanded and
differentiated into almost all cell types. Moreover, they are amenable to gene manipulation …

Latency reversal plus natural killer cells diminish HIV reservoir in vivo

JT Kim, TH Zhang, C Carmona, B Lee, CS Seet… - Nature …, 2022 - nature.com
HIV is difficult to eradicate due to the persistence of a long-lived reservoir of latently infected
cells. Previous studies have shown that natural killer cells are important to inhibiting HIV …

Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer's disease

A Faridar, M Vasquez, AD Thome, Z Yin… - Acta Neuropathologica …, 2022 - Springer
Abstract Background Regulatory T cells (Tregs) play a neuroprotective role by suppressing
microglia and macrophage-mediated inflammation and modulating adaptive immune …

Innovative strategies to improve the clinical application of NK cell-based immunotherapy

M Tarannum, R Romee, RM Shapiro - Frontiers in Immunology, 2022 - frontiersin.org
Natural killer cells constitute a part of the innate immune system that mediates an effective
immune response towards virus-infected and malignant cells. In recent years, research has …

The application of autologous cancer immunotherapies in the age of memory-NK cells

GD Lizana-Vasquez, M Torres-Lugo, RB Dixon… - Frontiers in …, 2023 - frontiersin.org
Cellular immunotherapy has revolutionized the oncology field, yielding improved results
against hematological and solid malignancies. NK cells have become an attractive …

[HTML][HTML] Natural killer cell therapy: A new frontier for obesity-associated cancer

E Mylod, J Lysaght, MJ Conroy - Cancer Letters, 2022 - Elsevier
Natural killer (NK) cell infiltration of solid tumours is associated with better outcomes, placing
augmentation of NK cell abundance in tumours as an attractive immunotherapeutic …

Metabolic adaptations determine whether natural killer cells fail or thrive within the tumor microenvironment

A Moinuddin, SM Poznanski, AL Portillo… - Immunological …, 2024 - Wiley Online Library
Natural Killer (NK) cells are a top contender in the development of adoptive cell therapies for
cancer due to their diverse antitumor functions and ability to restrict their activation against …

Proteome analysis of human natural killer cell derived extracellular vesicles for identification of anticancer effectors

JW Choi, S Lim, JH Kang, SH Hwang, KC Hwang… - Molecules, 2020 - mdpi.com
Cancer immunotherapy is a clinically validated therapeutic modality for cancer and has
been rapidly advancing in recent years. Adoptive transfer of immune cells such as T cells …

Design and implementation of NK cell-based immunotherapy to overcome the solid tumor microenvironment

I Navin, MT Lam, R Parihar - Cancers, 2020 - mdpi.com
Simple Summary Cell therapy over the last few years has revolutionized the treatment of
blood cancers. However, efficacy against cancers of solid organs remains limited. These …