Carboplatin is a derivative of cisplatin; it has a similar mechanism of action, but differs in
terms of structure and toxicity. It was approved by the FDA in the 1980s and since then it has …

The role of neoadjuvant chemotherapy (NACT) has been investigated in order to improve
prognosis of patients with locally advanced cervical cancer. According to a meta-analysis …

Background Aberrant spliced isoforms are specifically associated with cancer progression
and metastasis. The cytoplasmic adaptor CRKL (v-crk avian sarcoma virus CT10 oncogene …

Objective: To assess the efficacy and toxicity profile of dose-dense cisplatin-based
neoadjuvant chemotherapy (NACT) followed by radical surgery in patients affected by …

Aim: To assess preliminary results with dose-dense neoadjuvant chemotherapy (NACT)
prior to surgery or concurrent chemo-radiotherapy (CCRT) in cervical cancer. Patients and …

Platinum compounds have found wide application in the treatment of various types of cancer
and carboplatin is one of the main platinum-based drugs used as antitumor agents. The …

The aim of this study is to evaluate the outcome and safety of the multidisciplinary strategy
using cisplatin plus dose-dense paclitaxel (dose-dense TP) before and after radical …

Introduction There is an ongoing debate regarding the optimal local treatment modalities for
stage IB1 and IIA1 cervical cancer. The aim of this study was to determine whether radical …

Objective: To assess the efficacy and toxicity of the combination of paclitaxel plus
carboplatin as neoadjuvant chemotherapy (NACT) for locally advanced cervical cancer …

The purpose of this study is to investigate short-term efficacy as defined by the Response
Evaluation Criteria in Solid Tumors (RECIST) and pathological response of neoadjuvant …