Knocking on GDF15's door for the treatment of type 2 diabetes mellitus

D Aguilar-Recarte, E Barroso, X Palomer… - Trends in Endocrinology …, 2022 - cell.com
Although a large number of drugs are available for the treatment of type 2 diabetes mellitus
(T2DM), many patients do not achieve adequate disease control despite adhering to …

[HTML][HTML] MT1-MMP as a key regulator of metastasis

N Tanaka, T Sakamoto - Cells, 2023 - mdpi.com
Membrane type1-matrix metalloproteinase (MT1-MMP) is a member of metalloproteinases
that is tethered to the transmembrane. Its major function in cancer progression is to directly …

[HTML][HTML] Control of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2

X Guo, J Cao, JP Cai, J Wu, J Huang, P Asthana… - Nature …, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global
pandemic. Angiotensin-converting enzyme 2 (ACE2) is an entry receptor for SARS-CoV-2 …

[HTML][HTML] Artesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis

X Guo, P Asthana, L Zhai, KW Cheng, S Gurung… - Nature …, 2024 - nature.com
Obesity, a global health challenge, is a major risk factor for multiple life-threatening
diseases, including diabetes, fatty liver, and cancer. There is an ongoing need to identify …

[HTML][HTML] Maternal preconception body mass index overtakes age as a risk factor for gestational diabetes mellitus

M Mirabelli, V Tocci, A Donnici, S Giuliano… - Journal of Clinical …, 2023 - mdpi.com
Introduction—The purpose of this study was to determine the relative impact of modifiable
and non-modifiable risk factors in the development of gestational diabetes mellitus (GDM) …

Preventing obesity, insulin resistance and type 2 diabetes by targeting MT1-MMP

P Asthana, HLX Wong - Biochimica et Biophysica Acta (BBA)-Molecular …, 2024 - Elsevier
Obesity is one of the predominant risk factors for type 2 diabetes. Despite all the modern
advances in medicine, an effective drug treatment for obesity without overt side effects has …

β‐Aminoisobutyric Acid Relates to Favorable Glucose Metabolism through Adiponectin in Adults with Obesity Independent of Prediabetes

H Faiz, EM Heiston, SK Malin - Journal of Diabetes Research, 2023 - Wiley Online Library
β‐Aminoisobutyric acid (BAIBA) is secreted by skeletal muscle and promotes insulin
sensitivity, fat oxidation, and anti‐inflammation. While BAIBA is purportedly lower in …

[HTML][HTML] Maternal inflammatory, lipid and metabolic markers and associations with birth and breastfeeding outcomes

SH Christensen, AL Rom, T Greve, JI Lewis… - Frontiers in …, 2023 - frontiersin.org
Background Conditions in utero influence intrauterine and postnatal infant growth and a few
studies indicate that maternal inflammation and insulin resistance might affect birth and …

Proteolytic cleavage of membrane proteins by membrane type‐1 MMP regulates cancer malignant progression

K Ikeda, R Kaneko, E Tsukamoto, N Funahashi… - Cancer …, 2023 - Wiley Online Library
Strategies to develop cancer therapies using inhibitors that target matrix metalloproteinases
(MMPs), particularly membrane type‐1 MMP (MT1‐MMP), have failed. This is predominantly …

Insulin resistance is associated with the presence and severity of retinopathy in patients with type 2 diabetes

YX Xu, SD Pu, YT Zhang, XW Tong… - Clinical & …, 2024 - Wiley Online Library
Background To assess the relationship between novel insulin resistance (IR) indices and
the presence and severity of diabetic retinopathy (DR) in patients with type 2 diabetes …