Microglial cells: the main HIV-1 reservoir in the brain
C Wallet, M De Rovere, J Van Assche… - Frontiers in cellular …, 2019 - frontiersin.org
Despite efficient combination of the antiretroviral therapy (cART), which significantly
decreased mortality and morbidity of HIV-1 infection, a definitive HIV cure has not been …
decreased mortality and morbidity of HIV-1 infection, a definitive HIV cure has not been …
Gene editing and CRISPR in the clinic: current and future perspectives
Genome editing technologies, particularly those based on zinc-finger nucleases (ZFNs),
transcription activator-like effector nucleases (TALENs), and CRISPR (clustered regularly …
transcription activator-like effector nucleases (TALENs), and CRISPR (clustered regularly …
CRISPR/Cas9-based genome editing for disease modeling and therapy: challenges and opportunities for nonviral delivery
Genome editing offers promising solutions to genetic disorders by editing DNA sequences
or modulating gene expression. The clustered regularly interspaced short palindromic …
or modulating gene expression. The clustered regularly interspaced short palindromic …
CRISPR/Cas gene therapy
B Zhang - Journal of Cellular Physiology, 2021 - Wiley Online Library
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated
enzyme (Cas) is a naturally occurring genome editing tool adopted from the prokaryotic …
enzyme (Cas) is a naturally occurring genome editing tool adopted from the prokaryotic …
[HTML][HTML] Sequential LASER ART and CRISPR treatments eliminate HIV-1 in a subset of infected humanized mice
Elimination of HIV-1 requires clearance and removal of integrated proviral DNA from
infected cells and tissues. Here, sequential long-acting slow-effective release antiviral …
infected cells and tissues. Here, sequential long-acting slow-effective release antiviral …
[HTML][HTML] In vivo excision of HIV-1 provirus by saCas9 and multiplex single-guide RNAs in animal models
CRISPR-associated protein 9 (Cas9)-mediated genome editing provides a promising cure
for HIV-1/AIDS; however, gene delivery efficiency in vivo remains an obstacle to overcome …
for HIV-1/AIDS; however, gene delivery efficiency in vivo remains an obstacle to overcome …
[HTML][HTML] CRISPR-Cas systems: Overview, innovations and applications in human disease research and gene therapy
Y Xu, Z Li - Computational and Structural Biotechnology Journal, 2020 - Elsevier
Genome editing is the modification of genomic DNA at a specific target site in a wide variety
of cell types and organisms, including insertion, deletion and replacement of DNA, resulting …
of cell types and organisms, including insertion, deletion and replacement of DNA, resulting …
Engineering resistance against Tomato yellow leaf curl virus via the CRISPR/Cas9 system in tomato
ABSTRACT CRISPR/Cas systems confer molecular immunity against phages and
conjugative plasmids in prokaryotes. Recently, CRISPR/Cas9 systems have been used to …
conjugative plasmids in prokaryotes. Recently, CRISPR/Cas9 systems have been used to …
CRISPR based editing of SIV proviral DNA in ART treated non-human primates
Elimination of HIV DNA from infected individuals remains a challenge in medicine. Here, we
demonstrate that intravenous inoculation of SIV-infected macaques, a well-accepted non …
demonstrate that intravenous inoculation of SIV-infected macaques, a well-accepted non …
Drug delivery systems for CRISPR-based genome editors
V Madigan, F Zhang, JE Dahlman - Nature Reviews Drug Discovery, 2023 - nature.com
CRISPR-based drugs can theoretically manipulate any genetic target. In practice, however,
these drugs must enter the desired cell without eliciting an unwanted immune response, so …
these drugs must enter the desired cell without eliciting an unwanted immune response, so …