[HTML][HTML] Targeting regulated cell death in tumor nanomedicines

Q Zeng, X Ma, Y Song, Q Chen, Q Jiao, L Zhou - Theranostics, 2022 - ncbi.nlm.nih.gov
Nanomedicines hold great potential in anticancer therapy by modulating the biodistribution
of nanomaterials and initiating targeted oxidative stress damage, but they are also limited by …

A Distinctive Insight into Inorganic Sonosensitizers: Design Principles and Application Domains

W Qin, Q Yang, C Zhu, R Jiao, X Lin, C Fang, J Guo… - Small, 2024 - Wiley Online Library
Sonodynamic therapy (SDT) as a promising non‐invasive anti‐tumor means features the
preferable penetration depth, which nevertheless, usually can't work without …

Two-Dimensional MXene-Originated In Situ Nanosonosensitizer Generation for Augmented and Synergistic Sonodynamic Tumor Nanotherapy

M Zhang, D Yang, C Dong, H Huang, G Feng, Q Chen… - ACS …, 2022 - ACS Publications
Despite the merits of high tissue-penetrating depth, no ionizing radiation, and low cost,
sonodynamic therapy (SDT) still suffers from a low quantum yield of reactive oxygen species …

Immunogenic PANoptosis‐Initiated Cancer Sono‐Immune Reediting Nanotherapy by Iteratively Boosting Cancer Immunity Cycle

L Zhou, J Lyu, F Liu, Y Su, L Feng… - Advanced …, 2024 - Wiley Online Library
The cancer‐immune cycle conceptualized the mechanisms of driving T cell responses to
tumors, but w as limited by immunological ignorance elicited by tumor inherent …

Single Atom‐Doped Nanosonosensitizers for Mutually Optimized Sono/Chemo‐Nanodynamic Therapy of Triple Negative Breast Cancer

Q Chen, M Zhang, H Huang, C Dong, X Dai… - Advanced …, 2023 - Wiley Online Library
Sonodynamic therapy (SDT) represents a promising therapeutic modality for treating breast
cancer, which relies on the generation of abundant reactive oxygen species (ROS) to induce …

Nanomaterials-based tumor microenvironment modulation for magnifying sonodynamic therapy

L Song, L Lu, Y Pu, H Yin, K Zhang - Accounts of Materials …, 2022 - ACS Publications
Conspectus Sonodynamic therapy (SDT) is a noninvasive and more preferable therapeutic
modality than photodynamic therapy (PDT) due to deeper tissue penetration, which utilizes …

[HTML][HTML] Nanoengineered sonosensitive platelets for synergistically augmented sonodynamic tumor therapy by glutamine deprivation and cascading thrombosis

L Zhou, W Feng, Y Mao, Y Chen, X Zhang - Bioactive Materials, 2023 - Elsevier
Ultrasound (US)-activated sonodynamic therapy (SDT) stands for a distinct antitumor
modality because of its attractive characteristics including intriguing noninvasiveness …

Targeting acidogenic metabolism by engineering self-catalytic siRNA nanocarriers/nanocatalysts for amplified tumor apoptosis/ferroptosis

L Zhou, W Feng, L Chen, H Huang, S Huang, Q Chen… - Nano Today, 2022 - Elsevier
Nanocatalytic medicine holds great potential in inhibiting tumor progression based on the
synergistic catalytic production of toxic reactive oxygen species (ROS) between fenton …

[HTML][HTML] Selectively down-regulated PD-L1 by albumin-phenformin nanoparticles mediated mitochondrial dysfunction to stimulate tumor-specific immunological …

Z Zhou, N Jiang, J Chen, C Zheng, Y Guo, R Ye… - Journal of …, 2021 - Springer
Background Mild-temperature photothermal therapy (mild-PTT) has emerged as a highly
promising antitumor strategy by triggering immunogenic cell death (ICD) to elicit both innate …

Oncolytic impediment/promotion balance disruption by sonosensitizer-free nanoplatforms unfreezes autophagy-induced resistance to sonocatalytic therapy

L Lu, T Wang, C Fang, L Song, C Qian… - … Applied Materials & …, 2022 - ACS Publications
Autophagy as a double-edged sword features an oncolytic impediment/promotion balance,
which manipulates tumor progression. From this perspective, a sonosensitizer-free targeting …