Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection. Sepsis can be caused by a broad range of pathogens; however, bacterial …

Metabolomics, which is the metabolites profiling in biological matrices, is a key tool for
biomarker discovery and personalized medicine and has great potential to elucidate the …

Abstract The International Union of Immunological Societies (IUIS) expert committee (EC) on
Inborn Errors of Immunity (IEI) reports here the 2022 updated phenotypic classification …

Abstract Since 2013, the International Union of Immunological Societies (IUIS) expert
committee (EC) on Inborn Errors of Immunity (IEI) has published an updated phenotypic …

Since the 1990s, the International Union of Immunological Societies (IUIS) PID expert
committee (EC), now called Inborn Errors of Immunity Committee, has published every other …

Background Inborn errors of immunity (IEI) are rare diseases, which makes diagnosis a
challenge. A better description of the initial presenting manifestations should improve …

Introduction During the last 4 decades, registration of patients with primary
immunodeficiencies (PID) has played an essential role in different aspects of these diseases …

There are now nearly 300 single-gene inborn errors of immunity underlying phenotypes as
diverse as infection, malignancy, allergy, auto-immunity, and auto-inflammation. For each of …

Primary immunodeficiencies (PI) are genetic defects of the immune system that result in
chronic, serious, and often life-threatening infections, if not diagnosed and treated. Many …

Monogenic diseases of the immune system, also known as inborn errors of immunity, are
caused by single-gene mutations resulting in immune deficiency and dysregulation. More …