Alternatives to antibiotics—a pipeline portfolio review
L Czaplewski, R Bax, M Clokie, M Dawson… - The Lancet infectious …, 2016 - thelancet.com
Antibiotics have saved countless lives and enabled the development of modern medicine
over the past 70 years. However, it is clear that the success of antibiotics might only have …
over the past 70 years. However, it is clear that the success of antibiotics might only have …
A practical guide for probiotics applied to the case of antibiotic-associated diarrhea in The Netherlands
Background Antibiotic-associated diarrhea (AAD) is a side-effect frequently associated with
the use of broad spectrum antibiotics. Although a number of clinical studies show that co …
the use of broad spectrum antibiotics. Although a number of clinical studies show that co …
Toxicity induced by ciprofloxacin and enrofloxacin: oxidative stress and metabolism
S Badawy, YQ Yang, Y Liu, MA Marawan… - Critical Reviews in …, 2021 - Taylor & Francis
Abstract Ciprofloxacin (CIP)(human use) and enrofloxacin (ENR)(veterinary use) are
synthetic anti-infectious medications that belong to the second generation of …
synthetic anti-infectious medications that belong to the second generation of …
Host directed therapy against infection by boosting innate immunity
The innate immune system constitutes the first line of defense against invading pathogens,
regulating the normal microbiota and contributes to homeostasis. Today we have obtained …
regulating the normal microbiota and contributes to homeostasis. Today we have obtained …
LL-37: Review of antimicrobial profile against sensitive and antibiotic-resistant human bacterial pathogens
Background By the development of drug-resistant bacterial infections, the world is rapidly
heading toward the post-antibiotic era. Antimicrobial peptides are highly potential to be used …
heading toward the post-antibiotic era. Antimicrobial peptides are highly potential to be used …
New treatment approaches for Clostridioides difficile infections: alternatives to antibiotics and fecal microbiota transplantation
T Bratkovič, A Zahirović, M Bizjak, M Rupnik… - Gut …, 2024 - Taylor & Francis
Clostridioides difficile causes a range of debilitating intestinal symptoms that may be fatal. It
is particularly problematic as a hospital-acquired infection, causing significant costs to the …
is particularly problematic as a hospital-acquired infection, causing significant costs to the …
Single and mixture exposure to atrazine and ciprofloxacin on Clarias gariepinus antioxidant defense status, hepatic condition and immune response
IO Aguzie, CU Oriaku, FI Agbo, VO Ukwueze… - Environmental …, 2024 - Elsevier
Atrazine (ATRA) and ciprofloxacin (CPRO) are widely detected, persistent and co-existing
aquatic pollutants. This study investigated effects of 14-day single and joint ATRA and …
aquatic pollutants. This study investigated effects of 14-day single and joint ATRA and …
Targeted antibacterial activity guided by bacteria-specific nitroreductase catalytic activation to produce ciprofloxacin
Fluoroquinolones (FQs) are among the front-line antibiotics used to treat severe infections
caused by Gram-negative bacteria. However, recently, due to toxicity concerns, their use has …
caused by Gram-negative bacteria. However, recently, due to toxicity concerns, their use has …
IL-27 induces LL-37/CRAMP expression from intestinal epithelial cells: implications for immunotherapy of Clostridioides difficile infection
B Xu, X Wu, Y Gong, J Cao - Gut Microbes, 2021 - Taylor & Francis
Clostridioides difficile infection is currently the leading cause of nosocomial antibiotic-
associated diarrhea and pseudomembranous colitis worldwide. Cathelicidins, a major group …
associated diarrhea and pseudomembranous colitis worldwide. Cathelicidins, a major group …
Identifying hub genes of calcific aortic valve disease and revealing the immune infiltration landscape based on multiple WGCNA and single-cell sequence analysis
K Wang, Q Zheng, X Liu, BC Geng, NG Dong… - Frontiers in …, 2022 - frontiersin.org
Background Calcific aortic valve disease (CAVD) is a progressive fibrocalcific disease that
can be treated only through valve replacement. This study aimed to determine the role of …
can be treated only through valve replacement. This study aimed to determine the role of …