Conformational epitope-specific broadly neutralizing plasma antibodies obtained from an HIV-1 clade C-infected elite neutralizer mediate autologous virus escape …
Broadly neutralizing antibodies isolated from infected patients who are elite neutralizers
have identified targets on HIV-1 envelope (Env) glycoprotein that are vulnerable to antibody …
have identified targets on HIV-1 envelope (Env) glycoprotein that are vulnerable to antibody …
HIV gp120 H375 is unique to HIV-1 subtype CRF01_AE and confers strong resistance to the entry inhibitor BMS-599793, a candidate microbicide drug
SM Schader, SP Colby-Germinario… - Antimicrobial agents …, 2012 - Am Soc Microbiol
ABSTRACT BMS-599793 is a small molecule entry inhibitor that binds to human
immunodeficiency virus type 1 (HIV-1) gp120, resulting in the inhibition of CD4-dependent …
immunodeficiency virus type 1 (HIV-1) gp120, resulting in the inhibition of CD4-dependent …
[HTML][HTML] Subtle alteration of residues including N-linked glycans in V2 loop modulate HIV-1 neutralization by PG9 and PG16 monoclonal antibodies
Recent discovery of several potent and broadly neutralizing monoclonal antibodies
(MAbs)(such as PG9 and PG16) to HIV-1 provided clues on newer vaccine targets. In the …
(MAbs)(such as PG9 and PG16) to HIV-1 provided clues on newer vaccine targets. In the …
Cell surface ectodomain integrity of a subset of functional HIV-1 envelopes is dependent on a conserved hydrophilic domain containing region in their C-terminal tail
Background HIV-1 Env gp160 is cleaved to form gp120 and gp41 and the functional HIV-1
Env is a trimer of non-covalently associated heterodimeric subunits, gp120 and gp41. The …
Env is a trimer of non-covalently associated heterodimeric subunits, gp120 and gp41. The …
Association of enhanced HIV-1 neutralization by a single Y681H substitution in gp41 with increased gp120-CD4 interaction and macrophage infectivity
R Ringe, J Bhattacharya - PLoS One, 2012 - journals.plos.org
HIV-1 variants that show unusual sensitivity to autologous antibodies due to presence of
critical neutralization signatures would likely contribute towards rational envelope based HIV …
critical neutralization signatures would likely contribute towards rational envelope based HIV …
Stabilization of a soluble, native-like trimeric form of an efficiently cleaved Indian HIV-1 clade C envelope glycoprotein
Designing an effective HIV-1 envelope glycoprotein (Env) immunogen for elicitation of
broadly neutralizing antibodies (bNAbs) is a challenging task because of the high sequence …
broadly neutralizing antibodies (bNAbs) is a challenging task because of the high sequence …
Envelope proteins of two HIV-1 clades induced different epitope-specific antibody response
T Shrivastava, S Samal, AK Tyagi, S Goswami… - Vaccine, 2018 - Elsevier
Using HIV-1 envelope protein (Env)-based immunogens that closely mimic the conformation
of functional HIV-1 Envs and represent the isolates prevalent in relevant geographical …
of functional HIV-1 Envs and represent the isolates prevalent in relevant geographical …
Probing the structure of the HIV-1 envelope trimer using aspartate scanning mutagenesis
R Das, R Datta, R Varadarajan - Journal of Virology, 2020 - Am Soc Microbiol
ABSTRACT HIV-1 envelope (Env) glycoprotein gp160 exists as a trimer of heterodimers on
the viral surface. In most structures of the soluble ectodomain of trimeric HIV-1 envelope …
the viral surface. In most structures of the soluble ectodomain of trimeric HIV-1 envelope …
Characterization of a stable HIV-1 B/C recombinant, soluble, and trimeric envelope glycoprotein (Env) highly resistant to CD4-induced conformational changes
The HIV-1 envelope (Env) is a glycoprotein consisting of a trimer of heterodimers containing
gp120 and gp41 subunits that mediates virus entry and is a major target of broadly …
gp120 and gp41 subunits that mediates virus entry and is a major target of broadly …
[HTML][HTML] A single amino acid substitution in the C4 region in gp120 confers enhanced neutralization of HIV-1 by modulating CD4 binding sites and V3 loop
Identification of vulnerability in the HIV-1 envelope (Env) will aid in Env-based vaccine
design. We recently found an HIV-1 clade C Env clone (4–2. J45) amplified from a recently …
design. We recently found an HIV-1 clade C Env clone (4–2. J45) amplified from a recently …