Marine fungi: A source of potential anticancer compounds

SK Deshmukh, V Prakash, N Ranjan - Frontiers in microbiology, 2018 - frontiersin.org
Metabolites from marine fungi have hogged the limelight in drug discovery because of their
promise as therapeutic agents. A number of metabolites related to marine fungi have been …

Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs

J Popović-Djordjević, C Quispe, R Giordo… - European journal of …, 2022 - Elsevier
The human immunodeficiency virus (HIV) is responsible for acquired immune deficiency
syndrome (AIDS), one of the major pandemic diseases. Highly active antiretroviral therapy …

Nanodiamonds: the intersection of nanotechnology, drug development, and personalized medicine

D Ho, CHK Wang, EKH Chow - Science Advances, 2015 - science.org
The implementation of nanomedicine in cellular, preclinical, and clinical studies has led to
exciting advances ranging from fundamental to translational, particularly in the field of …

Immunometabolism and HIV-1 pathogenesis: food for thought

A Saez-Cirion, I Sereti - Nature reviews immunology, 2021 - nature.com
Antiretroviral therapies efficiently block HIV-1 replication but need to be maintained for life.
Moreover, chronic inflammation is a hallmark of HIV-1 infection that persists despite …

Environmental fate and ecotoxicological effects of antiretrovirals: a current global status and future perspectives

S Ncube, LM Madikizela, L Chimuka, MM Nindi - Water research, 2018 - Elsevier
The therapeutic efficacy of antiretroviral drugs as well as challenges and side effects against
the human immunodeficiency virus is well documented and reviewed. Evidence is available …

Adeno-associated virus delivery of anti-HIV monoclonal antibodies can drive long-term virologic suppression

JM Martinez-Navio, SP Fuchs, SN Pantry, WA Lauer… - Immunity, 2019 - cell.com
Long-term delivery of anti-HIV monoclonal antibodies (mAbs) using adeno-associated virus
(AAV) vectors holds promise for the prevention and treatment of HIV infection. We describe a …

Strategies to eradicate HIV from infected patients: elimination of latent provirus reservoirs

I Sadowski, FB Hashemi - Cellular and Molecular Life Sciences, 2019 - Springer
Abstract 35 years since identification of HIV as the causative agent of AIDS, and 35 million
deaths associated with this disease, significant effort is now directed towards the …

[HTML][HTML] Impact of antiretroviral therapy on lipid metabolism of human immunodeficiency virus-infected patients: Old and new drugs

J da Cunha, LMF Maselli, ACB Stern… - World journal of …, 2015 - ncbi.nlm.nih.gov
For human immunodeficiency virus (HIV)-infected patients, the 1990s were marked by the
introduction of highly active antiretroviral therapy (HAART) representing a new perspective …

Stimulating the RIG-I pathway to kill cells in the latent HIV reservoir following viral reactivation

P Li, P Kaiser, HW Lampiris, P Kim, SA Yukl… - Nature medicine, 2016 - nature.com
The persistence of latent HIV proviruses in long-lived CD4+ T cells despite antiretroviral
therapy (ART),, is a major obstacle to viral eradication,,. Because current candidate latency …

Novel assays for measurement of total cell-associated HIV-1 DNA and RNA

F Hong, E Aga, AR Cillo, AL Yates… - Journal of clinical …, 2016 - Am Soc Microbiol
Although a number of PCR-based quantitative assays for measuring HIV-1 persistence
during suppressive antiretroviral therapy (ART) have been reported, a simple, sensitive …