SAMHD1 functions and human diseases

SAA Coggins, B Mahboubi, RF Schinazi, B Kim - Viruses, 2020 - mdpi.com
Deoxynucleoside triphosphate (dNTP) molecules are essential for the replication and
maintenance of genomic information in both cells and a variety of viral pathogens. While the …

Dendritic cells, the double agent in the war against HIV-1

A Martín-Moreno, MA Muñoz-Fernández - Frontiers in immunology, 2019 - frontiersin.org
Human Immunodeficiency Virus (HIV) infects cells from the immune system and has thus
developed tools to circumvent the host immunity and use it in its advance. Dendritic cells …

GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia

M Chong, P Mohammadi-Shemirani, N Perrot… - Elife, 2022 - elifesciences.org
GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights
a potential causal role in dementia | eLife Skip to Content eLife logo eLife home page Menu …

Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification

CH Yu, A Bhattacharya, M Persaud, AB Taylor… - Nature …, 2021 - nature.com
SAMHD1 impedes infection of myeloid cells and resting T lymphocytes by retroviruses, and
the enzymatic activity of the protein—dephosphorylation of deoxynucleotide triphosphates …

SAMHD1 in cancer: curse or cure?

K Schott, C Majer, A Bulashevska, L Childs… - Journal of Molecular …, 2022 - Springer
Human sterile α motif and HD domain-containing protein 1 (SAMHD1), originally described
as the major cellular deoxyribonucleoside triphosphate triphosphohydrolase (dNTPase) …

[PDF][PDF] Важность цинка для поддержания активности белков врожденного противовирусного иммунитета: анализ публикаций, посвященных COVID-19

ОА Громова, ИЮ Торшин - Профилактическая медицина, 2020 - researchgate.net
РЕЗЮМЕ Введение. Компенсация сочетанных микронутриентных дефицитов—
важнейшее направление поддержки врожденного противовирусного иммунитета …

Elimination of Aicardi–Goutières syndrome protein SAMHD1 activates cellular innate immunity and suppresses SARS-CoV-2 replication

A Oo, K Zandi, C Shepard, LC Bassit, K Musall… - Journal of Biological …, 2022 - ASBMB
The lack of antiviral innate immune responses during severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infections is characterized by limited production of interferons …

Are evolution and the intracellular innate immune system key determinants in HIV transmission?

RP Sumner, LG Thorne, DL Fink, H Khan… - Frontiers in …, 2017 - frontiersin.org
HIV-1 is the single most important sexually transmitted disease in humans from a global
health perspective. Among human lentiviruses, HIV-1 M group has uniquely achieved …

[图书][B] Enzymatic and Chemical Synthesis of Nucleic Acid Derivatives

JF Lucas, MJC Rius - 2019 - books.google.com
A review of innovative tools for creative nucleic acid chemists that open the door to novel
probes and therapeutic agents Nucleic acids continue to gain importance as novel …

Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins

NE Bowen, J Temple, C Shepard, A Oo… - Journal of Biological …, 2021 - ASBMB
Elevated intracellular levels of dNTPs have been shown to be a biochemical marker of
cancer cells. Recently, a series of mutations in the multifunctional dNTP …