Multiple dysregulated signaling pathways are implicated in the pathogenesis of cancer. The
conventional therapies used in cancer prevention/treatment suffer from low efficacy …

Aging is a major risk factor in the development of chronic diseases affecting various tissues
including the cardiovascular system, muscle and bones. Age-related diseases are a …

Acute kidney injury (AKI) with high incidence and mortality is the main cause of chronic
kidney disease. Previous studies have indicated that quercetin, an abundant flavonoid in …

Background Diabetic kidney disease (DKD) is a primary microvascular complication of
diabetes. However, a complete cure for DKD has not yet been found. Although there is …

Rutin is a flavonoid present in many plant species. Because of its antioxidant, anti‐
inflammatory, and antiapoptotic properties, rutin is of interest for its potential protective …

Fibrosis, which is characterized by excessive extracellular matrix (ECM) deposition, is a
wound-healing response to organ injury and may promote cancer and failure in various …

Epidemiological studies have found that diabetes and cognitive dysfunction are closely
related. Quercetin has been certified with the effect on improving diabetes mellitus (DM) and …

Background Sepsis is a life-threatening condition caused by a dysregulated host response
to infection. Several studies have indicated that flavonoids exhibit a wide variety of biological …

Diabetic nephropathy (DN) is a renal complication of diabetic hyperglycemia. The Signal
transducer and activator of transcription 3 (Stat3) is a center molecule of the chronic …

Sepsis is a heterogenous and highly complex clinical syndrome, which is caused by
infectious or noninfectious factors. Acute kidney injury (AKI) is one of the most common and …