Phage display (Smith, 1985) was the first molecular diversity selection platform and the
conceptual forerunner of all subsequent molecular diversity techniques. An analysis of the …

Phagemids are filamentous-phage-derived vectors containing the replication origin of a
plasmid. Phagemids usually encode no or only one kind of coat proteins. Other structural …

The use of combinatorial Ig libraries displayed on the surface of bacteriophage has
advantages over traditional hybridoma techniques for the generation of mAbs but in many …

Inappropriate or excessive activation of the complement system can lead to harmful,
potentially life-threatening consequences due to severe inflammatory tissue destruction …

In addition to its essential role in immune defense, the complement system contributes to
tissue damage in many clinical conditions. Thus, there is a pressing need to develop …

Recombinant antibody technology is opening new perspectives for the development of
novel therapeutic and diagnostic agents. In this review we focus on advances in the …

Here we describe a phage display strategy for the selection of rabbit monoclonal antibodies
that recognize cell surface tumor-associated antigens expressed in prostate cancer. Two …

Molecular recognition guides the selective interaction of macromolecules with each other in
essentially all biological processes. Perhaps the most impactful use of biomolecular …

A combinatorial human IgG1, κ gene library of 2× 107 clones was constructed from a
pericolic lymph node using the phagemid vector pComb3H. Fabs with binding activity …

The invention relates to inhibitors that bind to C5 and C5a, but which do not prevent the
activation of C5 and do not prevent formation of or inhibit the activity of C5b. One example of …