Antibodies from phage antibody libraries
ARM Bradbury, JD Marks - Journal of immunological methods, 2004 - Elsevier
Phage display (Smith, 1985) was the first molecular diversity selection platform and the
conceptual forerunner of all subsequent molecular diversity techniques. An analysis of the …
conceptual forerunner of all subsequent molecular diversity techniques. An analysis of the …
Phagemid vectors for phage display: properties, characteristics and construction
H Qi, H Lu, HJ Qiu, V Petrenko, A Liu - Journal of molecular biology, 2012 - Elsevier
Phagemids are filamentous-phage-derived vectors containing the replication origin of a
plasmid. Phagemids usually encode no or only one kind of coat proteins. Other structural …
plasmid. Phagemids usually encode no or only one kind of coat proteins. Other structural …
Conversion of murine Fabs isolated from a combinatorial phage display library to full length immunoglobulins
RS Ames, MA Tornetta, K Deen, CS Jones… - Journal of …, 1995 - Elsevier
The use of combinatorial Ig libraries displayed on the surface of bacteriophage has
advantages over traditional hybridoma techniques for the generation of mAbs but in many …
advantages over traditional hybridoma techniques for the generation of mAbs but in many …
Controlling the complement system in inflammation
M Kirschfink - Immunopharmacology, 1997 - Elsevier
Inappropriate or excessive activation of the complement system can lead to harmful,
potentially life-threatening consequences due to severe inflammatory tissue destruction …
potentially life-threatening consequences due to severe inflammatory tissue destruction …
Complement inhibitors: a resurgent concept in anti-inflammatory therapeutics
A Sahu, JD Lambris - Immunopharmacology, 2000 - Elsevier
In addition to its essential role in immune defense, the complement system contributes to
tissue damage in many clinical conditions. Thus, there is a pressing need to develop …
tissue damage in many clinical conditions. Thus, there is a pressing need to develop …
Generation of recombinant antibodies
SM Kipriyanov, M Little - Molecular biotechnology, 1999 - Springer
Recombinant antibody technology is opening new perspectives for the development of
novel therapeutic and diagnostic agents. In this review we focus on advances in the …
novel therapeutic and diagnostic agents. In this review we focus on advances in the …
Isolation of human prostate cancer cell reactive antibodies using phage display technology
M Popkov, C Rader, CF Barbas III - Journal of immunological methods, 2004 - Elsevier
Here we describe a phage display strategy for the selection of rabbit monoclonal antibodies
that recognize cell surface tumor-associated antigens expressed in prostate cancer. Two …
that recognize cell surface tumor-associated antigens expressed in prostate cancer. Two …
Current trends in molecular recognition and bioseparation
C Jones, A Patel, S Griffin, J Martin, P Young… - … of chromatography A, 1995 - Elsevier
Molecular recognition guides the selective interaction of macromolecules with each other in
essentially all biological processes. Perhaps the most impactful use of biomolecular …
essentially all biological processes. Perhaps the most impactful use of biomolecular …
Retrieval of human antibodies from phage-display libraries using enzymatic cleavage
RL Ward, MA Clark, J Lees, NJ Hawkins - Journal of immunological …, 1996 - Elsevier
A combinatorial human IgG1, κ gene library of 2× 107 clones was constructed from a
pericolic lymph node using the phagemid vector pComb3H. Fabs with binding activity …
pericolic lymph node using the phagemid vector pComb3H. Fabs with binding activity …
Complement pathway inhibitors binding to C5 and C5a without preventing formation of C5b
M Fung, M Lu, WNC Sun, CRY Sun - US Patent 7,432,356, 2008 - Google Patents
The invention relates to inhibitors that bind to C5 and C5a, but which do not prevent the
activation of C5 and do not prevent formation of or inhibit the activity of C5b. One example of …
activation of C5 and do not prevent formation of or inhibit the activity of C5b. One example of …