ABSTRACT T-cell receptors recognize peptides presented by the major histocompatibility
complex (MHC) on the surface of antigen-presenting cells (APC). The ability of the T-cell …

The success of tumor immunotherapy targeting the inhibitory co-receptors PD-1 and CTLA-4
has indicated that many other co-receptors might be potential druggable targets, despite …

Reactive oxygen species (ROS/RNS) are produced during inflammation and elicit protein
modifications, but the immunological consequences are largely unknown. Gas plasma …

Preexisting T-cell immunity directed at conserved viral regions promotes enhanced recovery
from influenza virus infections, with there being some evidence of cross-protection directed …

The complex microbial community of the gastrointestinal tract plays an important role in an
animal's health by aiding digestion, producing nutrients, protecting against pathogens and in …

Measurements of thermal stability by circular dichroism (CD) spectroscopy have been widely
used to assess the binding of peptides to MHC proteins, particularly within the structural …

Hampering‐surface presentation of immunogenic peptides by class I/II MHCs is a key
strategy opted by several intracellular protozoan pathogens including Leishmania to escape …

Polymorphisms within HLA gene loci are strongly associated with susceptibility to
autoimmune disorders; however, it is not clear how genetic variations in these loci confer a …

Anti–PD-1 therapies can activate tumor-specific T cells to destroy tumors. However, whether
and how T cells with different antigen specificity and affinity are differentially regulated by PD …

Two-photon excitation microscopy (TPEM) has revolutionized the understanding of adaptive
immunity. However, TPEM usually requires animal models and is not amenable to the study …