Melatonin and 5-fluorouracil combination chemotherapy: opportunities and efficacy in cancer therapy
Combined chemotherapy is a treatment method based on the simultaneous use of two or
more therapeutic agents; it is frequently necessary to produce a more effective treatment for …
more therapeutic agents; it is frequently necessary to produce a more effective treatment for …
Melatonin: both a messenger of darkness and a participant in the cellular actions of non-visible solar radiation of near infrared light
Simple Summary Environmental light exposure is an important factor for human health that
impacts the biological clock of organisms. Melatonin usually serves as a chemical …
impacts the biological clock of organisms. Melatonin usually serves as a chemical …
Brain washing and neural health: role of age, sleep, and the cerebrospinal fluid melatonin rhythm
The brain lacks a classic lymphatic drainage system. How it is cleansed of damaged
proteins, cellular debris, and molecular by-products has remained a mystery for decades …
proteins, cellular debris, and molecular by-products has remained a mystery for decades …
Phytomelatonin: A master regulator for plant oxidative stress management
Phytomelatonin is the multifunctional molecule that governs a range of developmental
processes in plants subjected to a plethora of environmental cues. It acts as an antioxidant …
processes in plants subjected to a plethora of environmental cues. It acts as an antioxidant …
Aging-related ovarian failure and infertility: melatonin to the rescue
Aging has a major detrimental effect on the optimal function of the ovary with changes in this
organ preceding the age-related deterioration in other tissues, with the middle-aged …
organ preceding the age-related deterioration in other tissues, with the middle-aged …
Melatonin as a potential approach to anxiety treatment
Anxiety disorders are the most common mental diseases. Anxiety and the associated
physical symptoms may disturb social and occupational life and increase the risk of somatic …
physical symptoms may disturb social and occupational life and increase the risk of somatic …
Depression pathophysiology: Astrocyte mitochondrial melatonergic pathway as crucial hub
G Anderson - International Journal of Molecular Sciences, 2022 - mdpi.com
Major depressive disorder (MDD) is widely accepted as having a heterogenous
pathophysiology involving a complex mixture of systemic and CNS processes. A …
pathophysiology involving a complex mixture of systemic and CNS processes. A …
Melatonin modulates tumor metabolism and mitigates metastasis
Introduction Melatonin, originally isolated from the mammalian pineal gland, was
subsequently identified in many animal cell types and in plants. While melatonin was …
subsequently identified in many animal cell types and in plants. While melatonin was …
Melatonin reduces radiation-induced ferroptosis in hippocampal neurons by activating the PKM2/NRF2/GPX4 signaling pathway
C Ren, P Tan, L Gao, Y Zeng, S Hu, C Chen… - Progress in Neuro …, 2023 - Elsevier
Ferroptosis is a type of regulated cell death that is dependent on iron and reactive oxygen
species (ROS). Melatonin (N-acetyl-5-methoxytryptamine) reduces hypoxic–ischemic brain …
species (ROS). Melatonin (N-acetyl-5-methoxytryptamine) reduces hypoxic–ischemic brain …
Targeting microbiota to alleviate the harm caused by sleep deprivation
H Chen, C Wang, J Bai, J Song, L Bu, M Liang… - Microbiological …, 2023 - Elsevier
Sleep deprivation has become a common health hazard, affecting 37-58% of the population
and promoting the occurrence and development of many diseases. To date, effective …
and promoting the occurrence and development of many diseases. To date, effective …