Mycobacterium tuberculosis (Mtb) cultured axenically without detergent forms biofilm-like
cords, a clinical identifier of virulence. In lung-on-chip (LoC) and mouse models, cords in …

Summary Mycobacterium tuberculosis (Mtb) causes 1.6 million deaths annually. Active
tuberculosis correlates with a neutrophil-driven type I interferon (IFN) signature, but the …

Summary Mycobacterium tuberculosis (Mtb) infects 25% of the world's population and
causes tuberculosis (TB), which is a leading cause of death globally. A clear understanding …

Immunological priming—in the context of either prior infection or vaccination—elicits
protective responses against subsequent Mycobacterium tuberculosis (Mtb) infection …

Tuberculosis (TB) is one of the leading causes of death due to an infectious disease. The
rise of multi-drug resistance (MDR) in Mycobacterium tuberculosis (Mtb), the causative agent …

The spectinamides are novel, narrow-spectrum semisynthetic analogs of spectinomycin,
modified to avoid intrinsic efflux by Mycobacterium tuberculosis. Spectinamides, including …

Type I and III interferons (IFNs) both serve as pivotal components of the host antiviral innate
immune system. Although they exert similar antiviral effects, type I IFNs can also activate …

The crucial transmission phase of tuberculosis (TB) relies on infectious sputum and yet
cannot easily be modeled. We applied one-step RNA sequencing (RNA-Seq) to sputum …

Inflammation plays a crucial role in the control of Mycobacterium tuberculosis infection. In
this study, we demonstrate that an inflammatory pulmonary environment at the time of …

Efforts to develop more effective and shorter-course therapies for tuberculosis have included
a focus on host-directed therapy (HDT). The goal of HDT is to modulate the host response to …