Clinical significance of magnetic resonance imaging markers of vascular brain injury: a systematic review and meta-analysis
S Debette, S Schilling, MG Duperron… - JAMA …, 2019 - jamanetwork.com
Importance Covert vascular brain injury (VBI) is highly prevalent in community-dwelling
older persons, but its clinical and therapeutic implications are debated. Objective To better …
older persons, but its clinical and therapeutic implications are debated. Objective To better …
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Abstract Apolipoprotein E (Apo-E) is a major cholesterol carrier that supports lipid transport
and injury repair in the brain. APOE polymorphic alleles are the main genetic determinants …
and injury repair in the brain. APOE polymorphic alleles are the main genetic determinants …
Modifiable predictors of dementia in mild cognitive impairment: a systematic review and meta-analysis
Objective: Public health campaigns encouraging early help seeking have increased rates of
mild cognitive impairment (MCI) diagnosis in Western countries, but we know little about …
mild cognitive impairment (MCI) diagnosis in Western countries, but we know little about …
Mini‐Mental State Examination (MMSE) for the detection of Alzheimer's disease and other dementias in people with mild cognitive impairment (MCI)
I Arevalo‐Rodriguez, N Smailagic… - Cochrane database …, 2015 - cochranelibrary.com
Background Dementia is a progressive global cognitive impairment syndrome. In 2010,
more than 35 million people worldwide were estimated to be living with dementia. Some …
more than 35 million people worldwide were estimated to be living with dementia. Some …
[HTML][HTML] First-line avelumab in a cohort of 116 patients with metastatic Merkel cell carcinoma (JAVELIN Merkel 200): primary and biomarker analyses of a phase II …
Background Avelumab (anti-programmed death ligand 1 (PD-L1)) is approved in multiple
countries for the treatment of metastatic Merkel cell carcinoma (mMCC), a rare and …
countries for the treatment of metastatic Merkel cell carcinoma (mMCC), a rare and …
The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis
S Debette, HS Markus - Bmj, 2010 - bmj.com
Objectives To review the evidence for an association of white matter hyperintensities with
risk of stroke, cognitive decline, dementia, and death. Design Systematic review and meta …
risk of stroke, cognitive decline, dementia, and death. Design Systematic review and meta …
Brain imaging in Alzheimer disease
KA Johnson, NC Fox… - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Imaging has played a variety of roles in the study of Alzheimer disease (AD) over the past
four decades. Initially, computed tomography (CT) and then magnetic resonance imaging …
four decades. Initially, computed tomography (CT) and then magnetic resonance imaging …
The clinical use of structural MRI in Alzheimer disease
Structural imaging based on magnetic resonance is an integral part of the clinical
assessment of patients with suspected Alzheimer dementia. Prospective data on the natural …
assessment of patients with suspected Alzheimer dementia. Prospective data on the natural …
Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria
The NINCDS–ADRDA and the DSM-IV-TR criteria for Alzheimer's disease (AD) are the
prevailing diagnostic standards in research; however, they have now fallen behind the …
prevailing diagnostic standards in research; however, they have now fallen behind the …
Mild cognitive impairment
S Gauthier, B Reisberg, M Zaudig, RC Petersen… - The lancet, 2006 - thelancet.com
Mild cognitive impairment is a syndrome defined as cognitive decline greater than expected
for an individual's age and education level but that does not interfere notably with activities …
for an individual's age and education level but that does not interfere notably with activities …