Epigenetics of the developing and aging brain: Mechanisms that regulate onset and outcomes of brain reorganization

ER Bacon, RD Brinton - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
Brain development is a life-long process that encompasses several critical periods of
transition, during which significant cognitive changes occur. Embryonic development …

Transgenerational epigenetic impacts of parental infection on offspring health and disease susceptibility

EA Kleeman, C Gubert, AJ Hannan - Trends in Genetics, 2022 - cell.com
Maternal immune activation (MIA) and infection during pregnancy are known to
reprogramme offspring phenotypes. However, the epigenetic effects of preconceptual …

Prenatal stress and increased susceptibility to anxiety-like behaviors: role of neuroinflammation and balance between GABAergic and glutamatergic transmission

S Roshan-Milani, B Seyyedabadi, E Saboory… - Stress, 2021 - Taylor & Francis
Neuroplasticity during the prenatal period allows neurons to regenerate anatomically and
functionally for re-programming the brain development. During this critical period of fetal …

Investigating the effect of parental pre-gestational stress on ethological parameters in male rat offspring

N Azizi, M Heidari, E Saboory, N Abdollahzade… - Journal of Veterinary …, 2024 - Elsevier
Although extensive research has focused on the impact of maternal stress during
pregnancy, there remains a significant gap in understanding the influence of pre-pregnancy …

[HTML][HTML] A short pre-conception bout of predation risk affects both children and grandchildren

S Bhattacharya, PE MacCallum, M Dayma… - Scientific Reports, 2023 - nature.com
Traumatic events that affect physiology and behavior in the current generation may also
impact future generations. We demonstrate that an ecologically realistic degree of predation …

[HTML][HTML] Maternal inflammation induces spatial learning and memory impairment in the F1 and F2 generations of mice via sex-specific epigenetic mechanisms

ZZ Zhang, J Chen, BL Luo, MZ Ni, X Liu, LP Zeng… - Brain Research …, 2022 - Elsevier
Mounting evidence indicates that histone modifications are involved in aging-associated
cognitive decline (AACD) and can be transmitted to offspring over multiple generations …

Biological and behavioral pathways from prenatal depression to offspring cardiometabolic risk: Testing the developmental origins of health and disease hypothesis.

JR Doom, LBK Deer, D Dabelea… - Developmental …, 2024 - psycnet.apa.org
Given prior literature focused on the Developmental Origins of Health and Disease
framework, there is strong rationale to hypothesize that reducing depression in the prenatal …

Intergenerational effects of paternal predator cue exposure on behavior, stress reactivity, and neural gene expression

KE Brass, N Herndon, SA Gardner, JL Grindstaff… - Hormones and …, 2020 - Elsevier
Predation threat impacts prey behavior, physiology, and fitness. Stress-mediated alterations
to the paternal epigenome can be transmitted to offspring via the germline, conferring a …

[HTML][HTML] Inter-and transgenerational heritability of preconception chronic stress or alcohol exposure: Translational outcomes in brain and behavior

RC Rice, DV Gil, AM Baratta, RR Frawley, SY Hill… - Neurobiology of …, 2023 - Elsevier
Chronic stress and alcohol (ethanol) use are highly interrelated and can change an
individual's behavior through molecular adaptations that do not change the DNA sequence …

Paternal and/or maternal preconception-induced neurobehavioral teratogenicity in animal and human models

I Rimawi, A Ornoy, J Yanai - Brain Research Bulletin, 2021 - Elsevier
Prenatal insult exposure effects on the offspring, have and are still considered the main
interest of most teratological studies, while paternal and maternal preconception effects …