Epigenetics of the developing and aging brain: Mechanisms that regulate onset and outcomes of brain reorganization
ER Bacon, RD Brinton - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
Brain development is a life-long process that encompasses several critical periods of
transition, during which significant cognitive changes occur. Embryonic development …
transition, during which significant cognitive changes occur. Embryonic development …
Transgenerational epigenetic impacts of parental infection on offspring health and disease susceptibility
Maternal immune activation (MIA) and infection during pregnancy are known to
reprogramme offspring phenotypes. However, the epigenetic effects of preconceptual …
reprogramme offspring phenotypes. However, the epigenetic effects of preconceptual …
Prenatal stress and increased susceptibility to anxiety-like behaviors: role of neuroinflammation and balance between GABAergic and glutamatergic transmission
S Roshan-Milani, B Seyyedabadi, E Saboory… - Stress, 2021 - Taylor & Francis
Neuroplasticity during the prenatal period allows neurons to regenerate anatomically and
functionally for re-programming the brain development. During this critical period of fetal …
functionally for re-programming the brain development. During this critical period of fetal …
Investigating the effect of parental pre-gestational stress on ethological parameters in male rat offspring
Although extensive research has focused on the impact of maternal stress during
pregnancy, there remains a significant gap in understanding the influence of pre-pregnancy …
pregnancy, there remains a significant gap in understanding the influence of pre-pregnancy …
[HTML][HTML] A short pre-conception bout of predation risk affects both children and grandchildren
S Bhattacharya, PE MacCallum, M Dayma… - Scientific Reports, 2023 - nature.com
Traumatic events that affect physiology and behavior in the current generation may also
impact future generations. We demonstrate that an ecologically realistic degree of predation …
impact future generations. We demonstrate that an ecologically realistic degree of predation …
[HTML][HTML] Maternal inflammation induces spatial learning and memory impairment in the F1 and F2 generations of mice via sex-specific epigenetic mechanisms
ZZ Zhang, J Chen, BL Luo, MZ Ni, X Liu, LP Zeng… - Brain Research …, 2022 - Elsevier
Mounting evidence indicates that histone modifications are involved in aging-associated
cognitive decline (AACD) and can be transmitted to offspring over multiple generations …
cognitive decline (AACD) and can be transmitted to offspring over multiple generations …
Biological and behavioral pathways from prenatal depression to offspring cardiometabolic risk: Testing the developmental origins of health and disease hypothesis.
Given prior literature focused on the Developmental Origins of Health and Disease
framework, there is strong rationale to hypothesize that reducing depression in the prenatal …
framework, there is strong rationale to hypothesize that reducing depression in the prenatal …
Intergenerational effects of paternal predator cue exposure on behavior, stress reactivity, and neural gene expression
KE Brass, N Herndon, SA Gardner, JL Grindstaff… - Hormones and …, 2020 - Elsevier
Predation threat impacts prey behavior, physiology, and fitness. Stress-mediated alterations
to the paternal epigenome can be transmitted to offspring via the germline, conferring a …
to the paternal epigenome can be transmitted to offspring via the germline, conferring a …
[HTML][HTML] Inter-and transgenerational heritability of preconception chronic stress or alcohol exposure: Translational outcomes in brain and behavior
RC Rice, DV Gil, AM Baratta, RR Frawley, SY Hill… - Neurobiology of …, 2023 - Elsevier
Chronic stress and alcohol (ethanol) use are highly interrelated and can change an
individual's behavior through molecular adaptations that do not change the DNA sequence …
individual's behavior through molecular adaptations that do not change the DNA sequence …
Paternal and/or maternal preconception-induced neurobehavioral teratogenicity in animal and human models
Prenatal insult exposure effects on the offspring, have and are still considered the main
interest of most teratological studies, while paternal and maternal preconception effects …
interest of most teratological studies, while paternal and maternal preconception effects …