Although renowned as a lethal pathogen, Neisseria meningitidis has adapted to be a
commensal of the human nasopharynx. It shares extensive genetic and antigenic similarities …

Autotransporters are a superfamily of proteins that use the type V secretion pathway for their
delivery to the surface of Gram-negative bacteria. At first glance, autotransporters look to …

Autotransporters are a large and diverse superfamily of proteins produced by pathogenic
gram-negative bacteria that are composed of an N-terminal passenger domain, which …

The human species is the only natural host of Neisseria meningitidis, an important cause of
bacterial meningitis globally, and, despite its association with devastating diseases, N …

Neisseria meningitidis and Neisseria gonorrhoeae are globally important pathogens, which
in part owe their success to their ability to successfully evade human immune responses …

Autotransporters are the core component of a molecular nano-machine that delivers cargo
proteins across the outer membrane of Gram-negative bacteria. Part of the type V secretion …

During infection Neisseria meningitidis (Nm) encounters multiple environments within the
host, which makes rapid adaptation a crucial factor for meningococcal survival. Despite the …

The skull, spine, meninges, and cellular barriers at the blood–brain and the blood–
cerebrospinal fluid interfaces well protect the brain and meningeal spaces against microbial …

Phase-variation of genes is defined as the rapid and reversible switching of expression—
either ON-OFF switching or the expression of multiple allelic variants. Switching of …

Abstract Background Group B Streptococcus (GBS) is the leading cause of bacterial
meningitis in newborn infants. Because GBS is able to invade, survive, and cross the blood …