Microglia are implicated in all stages of multiple sclerosis (MS). Microglia alterations are
detected by positron emission tomography in people living with MS prior to the formation of …

Background Autism spectrum disorders (ASD) occur in 1.5% of the general population
worldwide. Studies suggest that ASD might have more costs than diabetes and attention …

INTRODUCTION The choroid plexus is a secretory epithelial tissue of the central nervous
system (CNS) responsible for cerebrospinal fluid (CSF) production and functions as a barrier …

Multiple sclerosis (MS) is an autoimmune, inflammatory neurodegenerative disease of the
central nervous system characterized by demyelination and axonal damage. Diagnosis and …

Inflammatory cytokines are necessary for an acute response to injury and the progressive
healing process. However, when this acute response does not resolve and becomes …

Astrocyte reactivation has been discovered to be an important contributor to several
neurological diseases. In vitro models involving human astrocytes have the potential to …

The innate immune landscape of the central nervous system (CNS), including the brain and
the retina, consists of different myeloid cell populations with distinct tasks to fulfill. Whereas …

Significance: Accumulating evidence suggests that inflammation is a major contributor in the
pathogenesis of several highly prevalent, but also rare, neurological diseases. In particular …

Neuroinflammatory and neurodegenerative diseases are characterized by the interplay of a
number of molecular pathways that can be assessed through biofluids, especially …

The advent of highly effective disease modifying therapy has transformed the landscape of
multiple sclerosis (MS) care over the last two decades. However, there remains a critical …