Obesity reaches up to epidemic proportions globally and increases the risk for a wide
spectrum of co-morbidities, including type-2 diabetes mellitus (T2DM), hypertension …

Insulin signaling via the insulin receptor (IR) may be associated with the amelioration of diet-
induced metabolic syndrome. Genistein, a soy isoflavone, has been suggested to play a role …

Nonalcoholic fatty liver disease (NAFLD) has emerged as the most widespread chronic liver
disease that poses significant threats to public health due to changes in dietary habits and …

Context Childhood overnutrition is associated with increased growth and bone mineral
density (BMD) vs the opposite for undernutrition. The role of insulin receptor (InsR) signaling …

Mesenchymal stem cells (MSCs) have been demonstrated to protect against fatty liver
diseases, but the mechanism is still not clear. Menstrual blood-derived endometrial stem …

Polycystic ovary syndrome (PCOS) is a common endocrine disorder, defined by
reproductive and endocrine abnormalities, with metabolic dysregulation including obesity …

Emerging evidence suggests that butyrate, a short-chain fatty acid, may have beneficial
effects on obesity and its associated metabolic comorbidities, but the related molecular …

Abstract Context Rabson-Mendenhall syndrome (RMS) is caused by biallelic pathogenic
variants in the insulin receptor gene (INSR) leading to insulin-resistant diabetes …

The prevalence of non-alcoholic fatty liver disease (NAFLD) is constantly increasing, and
altered expression of microRNAs (miRNAs) fosters the development and progression of …

BYL719 (alpelisib) is a small molecule inhibitor of PI3K p110α developed for cancer therapy.
Targeted suppression of PI3K has led to lifespan extension in rodents and model organisms …