The language of chromatin modification in human cancers
The genetic information of human cells is stored in the context of chromatin, which is
subjected to DNA methylation and various histone modifications. Such a 'language'of …
subjected to DNA methylation and various histone modifications. Such a 'language'of …
NPM1-mutated acute myeloid leukemia: from bench to bedside
The nucleophosmin (NPM1) gene encodes for a multifunctional protein with prominent
nucleolar localization that shuttles between nucleus and cytoplasm. NPM1 mutations …
nucleolar localization that shuttles between nucleus and cytoplasm. NPM1 mutations …
Hallmarks of cancer—the new testament
SS Senga, RP Grose - Open biology, 2021 - royalsocietypublishing.org
Diagnosis and treatment of disease demand a sound understanding of the underlying
mechanisms, determining any Achilles' heel that can be targeted in effective therapies …
mechanisms, determining any Achilles' heel that can be targeted in effective therapies …
[HTML][HTML] Leukemic stem cells and therapy resistance in acute myeloid leukemia
P Stelmach, A Trumpp - Haematologica, 2023 - ncbi.nlm.nih.gov
A major obstacle in the treatment of acute myeloid leukemia (AML) is refractory disease or
relapse after achieving remission. The latter arises from a few therapy-resistant cells within …
relapse after achieving remission. The latter arises from a few therapy-resistant cells within …
Epigenetic plasticity and the hallmarks of cancer
WA Flavahan, E Gaskell, BE Bernstein - Science, 2017 - science.org
BACKGROUND Chromatin is the essential medium through which transcription factors,
signaling pathways, and other cues alter gene activity and cellular phenotypes. It assumes …
signaling pathways, and other cues alter gene activity and cellular phenotypes. It assumes …
Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion
Patients with acute myeloid leukaemia (AML) often achieve remission after therapy, but
subsequently die of relapse that is driven by chemotherapy-resistant leukaemic stem cells …
subsequently die of relapse that is driven by chemotherapy-resistant leukaemic stem cells …
Therapy-related clonal hematopoiesis in patients with non-hematologic cancers is common and associated with adverse clinical outcomes
Clonal hematopoiesis (CH), as evidenced by recurrent somatic mutations in leukemia-
associated genes, commonly occurs among aging human hematopoietic stem cells. We …
associated genes, commonly occurs among aging human hematopoietic stem cells. We …
Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation
Somatic mutations in cancer genes have been detected in clonal expansions across healthy
human tissue, including in clonal hematopoiesis. However, because mutated and wild-type …
human tissue, including in clonal hematopoiesis. However, because mutated and wild-type …
The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions
We present the molecular landscape of pediatric acute myeloid leukemia (AML) and
characterize nearly 1,000 participants in Children's Oncology Group (COG) AML trials. The …
characterize nearly 1,000 participants in Children's Oncology Group (COG) AML trials. The …