Caspase-3 is a widely expressed member of a conserved family of proteins, generally
recognized for their activated proteolytic roles in the execution of apoptosis in cells …

Erythropoiesis is a multi‐step process that involves the differentiation of hematopoietic stem
cells into mature red blood cells (RBCs). This process is regulated by several signaling …

Human erythropoiesis serves as a paradigm of physiologic cellular differentiation. This
process is also of considerable interest for better understanding anemias and identifying …

The mitochondrial caspase cascade was originally thought to be required for apoptotic
death driven by Bak/Bax-mediated intrinsic apoptosis. It has also been ascribed several 'non …

Chicken erythrocytes are nucleated cells often considered to be transcriptionally inactive,
although the epigenetic changes and chromatin remodeling that would mediate …

A characteristic feature of terminal erythropoiesis in mammals is extrusion of the highly
condensed nucleus out of the cytoplasm. Other vertebrates, including fish, reptiles …

Abstract β-Thalassemia (BT) is an inherited genetic disorder that is characterized by
ineffective erythropoiesis (IE), leading to anemia and abnormal iron metabolism. IE is an …

Cell viability assessment is critical, yet existing assessments are not accurate enough. We
report a cell viability evaluation method based on the metabolic ability of a single cell …

Highlights•Enucleation is a rate-limiting step in erythropoiesis that leads to the formation of
RBCs.•Regulators of enucleation range from transcription factors to miRNAs.•Optimum …

Congenital dyserythropoietic anaemia type I (CDA‐I) is one of a heterogeneous group of
inherited anaemias characterised by ineffective erythropoiesis. CDA‐I is caused by bi‐allelic …