Monocytes are innate blood cells that maintain vascular homeostasis and are early
responders to pathogens in acute infections. There are three well-characterized classes of …

Mouse and human FcRs have been a major focus of attention not only of the scientific
community, through the cloning and characterization of novel receptors, and of the medical …

Caspase-dependent apoptosis accounts for approximately 90% of homeostatic cell turnover
in the body, and regulates inflammation, cell proliferation, and tissue regeneration,–. How …

Rheumatoid Arthritis (RA) is an autoimmune systemic disorder of unknown etiology and is
characterized by chronic inflammation and synovial infiltration of immune cells. RA is …

Impressive advances in defining the properties of receptors for the Fc portion of
immunoglobulins (FcR) have been made over the past several years. Ligand specificities …

The immune system responds to pathogens by a variety of pattern recognition molecules
such as the Toll-like receptors (TLRs), which promote recognition of dangerous foreign …

Although the control of bone-resorbing osteoclasts through osteocyte-derived RANKL is well
defined, little is known about the regulation of osteoclasts by osteocyte death. Indeed …

Synovial joints are complex structures that enable normal locomotion. Following injury, they
undergo a series of changes, including a prevalent inflammatory response. This increases …

Commensal microbes can have a substantial impact on autoimmune disorders, but the
underlying molecular and cellular mechanisms remain largely unexplored. We report that …

Granulocytes and monocytes/macrophages of the myeloid lineage are the chief cellular
agents of innate immunity. Here, we have examined the inflammatory response in mice with …