Occlusive arterial disease is a leading cause of morbidity and mortality worldwide. Aside
from balloon angioplasty, bypass graft surgery is the most commonly performed …

OBJECTIVE: To develop a set of suggested objective performance goals (OPG) for
evaluating new catheter-based treatments in critical limb ischemia (CLI), based on evidence …

BACKGROUND: A 2005 interim analysis of the Bypass versus Angioplasty in Severe
Ischaemia of the Leg (BASIL) trial showed that in patients with severe lower limb ischemia …

OBJECTIVE: The PREVENT III study was a prospective, randomized, double-blinded,
multicenter phase III trial of a novel molecular therapy (edifoligide; E2F decoy) for the …

OBJECTIVE: The influence of operator-dependent variables on the outcomes of lower
extremity bypass (LEB) surgery have primarily been reported in single-institution …

BACKGROUND: Patients with critical limb ischemia (CLI) are a heterogeneous population
with respect to risk for mortality and limb loss, complicating clinical decision-making …

Background—Vein bypass surgery is an effective therapy for atherosclerotic occlusive
disease in the coronary and peripheral circulations; however, long-term results are limited …

OBJECTIVES: Patients who require infrainguinal revascularization for critical limb ischemia
(CLI) are at elevated risk for cardiovascular events. The PREVENT III study was a …

OBJECTIVE: Evidence suggesting a beneficial effect of cardioprotective medications in
patients with lower extremity atherosclerosis derives largely from secondary prevention …

BACKGROUND: Patients with critical limb ischemia (CLI) have multiple comorbidities and
limited life spans. The ability of infrainguinal vein bypass to improve quality of life (QoL) in …