[PDF][PDF] GDF15: a hormone conveying somatic distress to the brain
GDF15 has recently gained scientific and translational prominence with the discovery that its
receptor is a GFRAL-RET heterodimer of which GFRAL is expressed solely in the hindbrain …
receptor is a GFRAL-RET heterodimer of which GFRAL is expressed solely in the hindbrain …
COVID-19 and crosstalk with the hallmarks of aging
Within the past several decades, the emergence of new viral diseases with severe health
complications and mortality is evidence of an age-dependent, compromised bodily response …
complications and mortality is evidence of an age-dependent, compromised bodily response …
[HTML][HTML] GDF15, an update of the physiological and pathological roles it plays: a review
Abstract Growth differentiation factor 15 (GDF15) is a peptide hormone, and a divergent
member of the transforming growth factor beta (TGFβ) superfamily. In normal physiology …
member of the transforming growth factor beta (TGFβ) superfamily. In normal physiology …
[HTML][HTML] Electroanalytical point-of-care detection of gold standard and emerging cardiac biomarkers for stratification and monitoring in intensive care medicine-a …
RD Crapnell, NC Dempsey, E Sigley, A Tridente… - Microchimica Acta, 2022 - Springer
Determination of specific cardiac biomarkers (CBs) during the diagnosis and management
of adverse cardiovascular events such as acute myocardial infarction (AMI) has become …
of adverse cardiovascular events such as acute myocardial infarction (AMI) has become …
[HTML][HTML] GDF15 as a key disease target and biomarker: Linking chronic lung diseases and ageing
Y Wan, J Fu - Molecular and cellular biochemistry, 2024 - Springer
Abstract Growth differentiation factor 15 (GDF15), a member of the transforming growth
factor-beta superfamily, is expressed in several human organs. In particular, it is highly …
factor-beta superfamily, is expressed in several human organs. In particular, it is highly …
[HTML][HTML] A systematic review of biomarkers multivariately associated with acute respiratory distress syndrome development and mortality
P Van Der Zee, W Rietdijk, P Somhorst, H Endeman… - Critical Care, 2020 - Springer
Background Heterogeneity of acute respiratory distress syndrome (ARDS) could be reduced
by identification of biomarker-based phenotypes. The set of ARDS biomarkers to …
by identification of biomarker-based phenotypes. The set of ARDS biomarkers to …
Increased expression of GDF-15 may mediate ICU-acquired weakness by down-regulating muscle microRNAs
SAA Bloch, JY Lee, T Syburra, U Rosendahl… - Thorax, 2015 - thorax.bmj.com
Rationale The molecular mechanisms underlying the muscle atrophy of intensive care unit-
acquired weakness (ICUAW) are poorly understood. We hypothesised that increased …
acquired weakness (ICUAW) are poorly understood. We hypothesised that increased …
[HTML][HTML] Pathophysiology and biomarkers of acute respiratory distress syndrome
S Fujishima - Journal of intensive care, 2014 - Springer
Acute respiratory distress syndrome (ARDS) is defined as an acute-onset, progressive,
hypoxic condition with radiographic bilateral lung infiltration, which develops after several …
hypoxic condition with radiographic bilateral lung infiltration, which develops after several …
Growth differentiation factor‐15 is a predictor of mortality in critically ill patients with sepsis
L Buendgens, E Yagmur, J Bruensing… - Disease …, 2017 - Wiley Online Library
Growth differentiation factor‐15 (GDF‐15) is a member of the transforming growth factor‐β
superfamily related to inflammation and macrophage activation. Serum concentrations of …
superfamily related to inflammation and macrophage activation. Serum concentrations of …
[HTML][HTML] Role of growth differentiation factor 15 in lung disease and senescence: potential role across the lifespan
F Al-Mudares, S Reddick, J Ren, A Venkatesh… - Frontiers in …, 2020 - frontiersin.org
Growth Differentiation Factor 15 (GDF15) is a divergent member of transforming growth
factor-beta (TGF-β) superfamily and is ubiquitously expressed, under normal physiological …
factor-beta (TGF-β) superfamily and is ubiquitously expressed, under normal physiological …